Sleep, Adenosine, and Neurodegeneration

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Sleep is a complex, critical behavior that is under the control of homeostatic and circadian processes. Homeostatic sleep reflects increasing sleep drive or need in correlation with waking duration and its resolution during sleep. It is mediated in large part through the adenosine (ado) system. Ageing results in changes in the ado system and, often, complaints of sleep disturbance. Sleep disturbance is a common symptom across neurodegenerative diseases and greatly impacts quality of life. In this chapter we will discuss two relatively common neurodegenerative diseases, Alzheimer's (AD) and Parkinson's (PD), which together encapsulate many of the sleep disturbances associated with neurodegenerative disease. In regards to AD, there is emerging evidence of a bidirectional influence of AD and sleep disruption. Alternatively, in regards to PD, parasomnias can herald neurodegeneration several years prior to appearance of characteristic motor symptoms. Additionally, the ado system as a possible therapeutic target will be briefly discussed.

Original languageEnglish (US)
Title of host publicationAdenosine Receptors in Neurodegenerative Diseases
PublisherElsevier Inc.
Pages111-130
Number of pages20
ISBN (Electronic)9780128037454
ISBN (Print)9780128037249
DOIs
StatePublished - Mar 30 2017

Fingerprint

Adenosine
Sleep
Neurodegenerative Diseases
Parasomnias
Quality of Life

Keywords

  • Alzheimer's
  • NREM
  • Parasomnias
  • Parkinson's
  • REM
  • Sleep deprivation

ASJC Scopus subject areas

  • Medicine(all)
  • Neuroscience(all)

Cite this

Bjorness, T. E., & Greene, R. W. (2017). Sleep, Adenosine, and Neurodegeneration. In Adenosine Receptors in Neurodegenerative Diseases (pp. 111-130). Elsevier Inc.. https://doi.org/10.1016/B978-0-12-803724-9.00006-5

Sleep, Adenosine, and Neurodegeneration. / Bjorness, Theresa E.; Greene, Robert W.

Adenosine Receptors in Neurodegenerative Diseases. Elsevier Inc., 2017. p. 111-130.

Research output: Chapter in Book/Report/Conference proceedingChapter

Bjorness, TE & Greene, RW 2017, Sleep, Adenosine, and Neurodegeneration. in Adenosine Receptors in Neurodegenerative Diseases. Elsevier Inc., pp. 111-130. https://doi.org/10.1016/B978-0-12-803724-9.00006-5
Bjorness TE, Greene RW. Sleep, Adenosine, and Neurodegeneration. In Adenosine Receptors in Neurodegenerative Diseases. Elsevier Inc. 2017. p. 111-130 https://doi.org/10.1016/B978-0-12-803724-9.00006-5
Bjorness, Theresa E. ; Greene, Robert W. / Sleep, Adenosine, and Neurodegeneration. Adenosine Receptors in Neurodegenerative Diseases. Elsevier Inc., 2017. pp. 111-130
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