Sleep architecture in children and adolescents with cystic fibrosis and the association with severity of lung disease

S. Kamal Naqvi, Carlos Sotelo, Lisa Murry, Narong Simakajornboon

Research output: Contribution to journalArticle

48 Citations (Scopus)

Abstract

Previous studies have shown that sleep complaints are common in adult patients with cystic fibrosis (CF). However, there is very little data on sleep in children and adolescents with CF and the association with severity of lung disease. A prospective study was conducted in CF children and age-matched controls. All patients completed sleep questionnaire and underwent an overnight polysomnographic study. Thirty-eight children and adolescents met the criteria for entry into the analysis, 24 children and adolescents with CF (S) and 14 controls (C). Sleep complaints were common in children and adolescents with CF; 43.5% reported sleep onset problem, 39.1% reported sleep maintenance problem, 30.4% were noted to snore at night, and 73.9% reported daytime sleepiness. Children and adolescents with CF had a significant decrease in sleep efficiency [SE; 75.2±2.5% (S) vs 85.6±1.7%(C); P<0.01], prolonged rapid eye movement (REM) latency [150.5±16.6 min (S) vs 85.6±11.0 min (C); P<0.05], and reduction in percentage of REM sleep [12.7±1.5% (S) vs 18.3±1.3% (C); P<0.05]. The degree of sleep disruption as indicated by SE was correlated with forced expiratory volume in one second (FEV1; r=0.52, P<0.05). However, there was no significant correlation between SE and minimum oxygen saturation [r=0.30, P=not significant (NS)] or SE and maximal end-tidal pCO2 (r=0.11, P=NS). It is concluded that children and adolescents with CF have frequent sleep complaints and significant alteration in the sleep architecture. The magnitude of sleep disruption is associated with severity of lung disease, but is not directly correlated with the degree of nocturnal hypoxemia or hypoventilation. It is speculated that sleep disruption in children and adolescents with CF may have an impact on quality of life and clinical outcomes in this population.

Original languageEnglish (US)
Pages (from-to)77-83
Number of pages7
JournalSleep and Breathing
Volume12
Issue number1
DOIs
StatePublished - Feb 2008

Fingerprint

Cystic Fibrosis
Lung Diseases
Sleep
REM Sleep
Hypoventilation
Forced Expiratory Volume
Maintenance
Quality of Life
Prospective Studies
Oxygen

Keywords

  • Chronic lung disease
  • Cystic fibrosis
  • Lung function
  • Sleep architecture
  • Sleep disruption

ASJC Scopus subject areas

  • Otorhinolaryngology

Cite this

Sleep architecture in children and adolescents with cystic fibrosis and the association with severity of lung disease. / Naqvi, S. Kamal; Sotelo, Carlos; Murry, Lisa; Simakajornboon, Narong.

In: Sleep and Breathing, Vol. 12, No. 1, 02.2008, p. 77-83.

Research output: Contribution to journalArticle

Naqvi, S. Kamal ; Sotelo, Carlos ; Murry, Lisa ; Simakajornboon, Narong. / Sleep architecture in children and adolescents with cystic fibrosis and the association with severity of lung disease. In: Sleep and Breathing. 2008 ; Vol. 12, No. 1. pp. 77-83.
@article{f3bfd71ab0d84e0d8c4c38cc3b87d456,
title = "Sleep architecture in children and adolescents with cystic fibrosis and the association with severity of lung disease",
abstract = "Previous studies have shown that sleep complaints are common in adult patients with cystic fibrosis (CF). However, there is very little data on sleep in children and adolescents with CF and the association with severity of lung disease. A prospective study was conducted in CF children and age-matched controls. All patients completed sleep questionnaire and underwent an overnight polysomnographic study. Thirty-eight children and adolescents met the criteria for entry into the analysis, 24 children and adolescents with CF (S) and 14 controls (C). Sleep complaints were common in children and adolescents with CF; 43.5{\%} reported sleep onset problem, 39.1{\%} reported sleep maintenance problem, 30.4{\%} were noted to snore at night, and 73.9{\%} reported daytime sleepiness. Children and adolescents with CF had a significant decrease in sleep efficiency [SE; 75.2±2.5{\%} (S) vs 85.6±1.7{\%}(C); P<0.01], prolonged rapid eye movement (REM) latency [150.5±16.6 min (S) vs 85.6±11.0 min (C); P<0.05], and reduction in percentage of REM sleep [12.7±1.5{\%} (S) vs 18.3±1.3{\%} (C); P<0.05]. The degree of sleep disruption as indicated by SE was correlated with forced expiratory volume in one second (FEV1; r=0.52, P<0.05). However, there was no significant correlation between SE and minimum oxygen saturation [r=0.30, P=not significant (NS)] or SE and maximal end-tidal pCO2 (r=0.11, P=NS). It is concluded that children and adolescents with CF have frequent sleep complaints and significant alteration in the sleep architecture. The magnitude of sleep disruption is associated with severity of lung disease, but is not directly correlated with the degree of nocturnal hypoxemia or hypoventilation. It is speculated that sleep disruption in children and adolescents with CF may have an impact on quality of life and clinical outcomes in this population.",
keywords = "Chronic lung disease, Cystic fibrosis, Lung function, Sleep architecture, Sleep disruption",
author = "Naqvi, {S. Kamal} and Carlos Sotelo and Lisa Murry and Narong Simakajornboon",
year = "2008",
month = "2",
doi = "10.1007/s11325-007-0123-0",
language = "English (US)",
volume = "12",
pages = "77--83",
journal = "Sleep and Breathing",
issn = "1520-9512",
publisher = "Springer Verlag",
number = "1",

}

TY - JOUR

T1 - Sleep architecture in children and adolescents with cystic fibrosis and the association with severity of lung disease

AU - Naqvi, S. Kamal

AU - Sotelo, Carlos

AU - Murry, Lisa

AU - Simakajornboon, Narong

PY - 2008/2

Y1 - 2008/2

N2 - Previous studies have shown that sleep complaints are common in adult patients with cystic fibrosis (CF). However, there is very little data on sleep in children and adolescents with CF and the association with severity of lung disease. A prospective study was conducted in CF children and age-matched controls. All patients completed sleep questionnaire and underwent an overnight polysomnographic study. Thirty-eight children and adolescents met the criteria for entry into the analysis, 24 children and adolescents with CF (S) and 14 controls (C). Sleep complaints were common in children and adolescents with CF; 43.5% reported sleep onset problem, 39.1% reported sleep maintenance problem, 30.4% were noted to snore at night, and 73.9% reported daytime sleepiness. Children and adolescents with CF had a significant decrease in sleep efficiency [SE; 75.2±2.5% (S) vs 85.6±1.7%(C); P<0.01], prolonged rapid eye movement (REM) latency [150.5±16.6 min (S) vs 85.6±11.0 min (C); P<0.05], and reduction in percentage of REM sleep [12.7±1.5% (S) vs 18.3±1.3% (C); P<0.05]. The degree of sleep disruption as indicated by SE was correlated with forced expiratory volume in one second (FEV1; r=0.52, P<0.05). However, there was no significant correlation between SE and minimum oxygen saturation [r=0.30, P=not significant (NS)] or SE and maximal end-tidal pCO2 (r=0.11, P=NS). It is concluded that children and adolescents with CF have frequent sleep complaints and significant alteration in the sleep architecture. The magnitude of sleep disruption is associated with severity of lung disease, but is not directly correlated with the degree of nocturnal hypoxemia or hypoventilation. It is speculated that sleep disruption in children and adolescents with CF may have an impact on quality of life and clinical outcomes in this population.

AB - Previous studies have shown that sleep complaints are common in adult patients with cystic fibrosis (CF). However, there is very little data on sleep in children and adolescents with CF and the association with severity of lung disease. A prospective study was conducted in CF children and age-matched controls. All patients completed sleep questionnaire and underwent an overnight polysomnographic study. Thirty-eight children and adolescents met the criteria for entry into the analysis, 24 children and adolescents with CF (S) and 14 controls (C). Sleep complaints were common in children and adolescents with CF; 43.5% reported sleep onset problem, 39.1% reported sleep maintenance problem, 30.4% were noted to snore at night, and 73.9% reported daytime sleepiness. Children and adolescents with CF had a significant decrease in sleep efficiency [SE; 75.2±2.5% (S) vs 85.6±1.7%(C); P<0.01], prolonged rapid eye movement (REM) latency [150.5±16.6 min (S) vs 85.6±11.0 min (C); P<0.05], and reduction in percentage of REM sleep [12.7±1.5% (S) vs 18.3±1.3% (C); P<0.05]. The degree of sleep disruption as indicated by SE was correlated with forced expiratory volume in one second (FEV1; r=0.52, P<0.05). However, there was no significant correlation between SE and minimum oxygen saturation [r=0.30, P=not significant (NS)] or SE and maximal end-tidal pCO2 (r=0.11, P=NS). It is concluded that children and adolescents with CF have frequent sleep complaints and significant alteration in the sleep architecture. The magnitude of sleep disruption is associated with severity of lung disease, but is not directly correlated with the degree of nocturnal hypoxemia or hypoventilation. It is speculated that sleep disruption in children and adolescents with CF may have an impact on quality of life and clinical outcomes in this population.

KW - Chronic lung disease

KW - Cystic fibrosis

KW - Lung function

KW - Sleep architecture

KW - Sleep disruption

UR - http://www.scopus.com/inward/record.url?scp=38349139839&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=38349139839&partnerID=8YFLogxK

U2 - 10.1007/s11325-007-0123-0

DO - 10.1007/s11325-007-0123-0

M3 - Article

C2 - 17610099

AN - SCOPUS:38349139839

VL - 12

SP - 77

EP - 83

JO - Sleep and Breathing

JF - Sleep and Breathing

SN - 1520-9512

IS - 1

ER -