Sleep, feeding, and neuropeptides: Roles of orexins and orexin receptors

Michihiro Mieda, Masashi Yanagisawa

Research output: Contribution to journalArticle

84 Citations (Scopus)

Abstract

Recent studies using molecular genetics in mice and dogs, as well as histopathological analyses of human disease, have come to the same conclusion: the human sleep disorder narcolepsy is caused by failure of signaling mediated by orexin (hypocretin) neuropeptides. These and other findings strongly suggest that the orexin system plays a critical role in sleep/wake regulation. In addition, the orexin system may link energy homeostasis to the regulation of sleep/wake cycles.

Original languageEnglish (US)
Pages (from-to)339-345
Number of pages7
JournalCurrent Opinion in Neurobiology
Volume12
Issue number3
DOIs
StatePublished - Jun 1 2002

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Orexin Receptors
Neuropeptides
Sleep
Narcolepsy
Molecular Biology
Homeostasis
Dogs
Orexins

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Sleep, feeding, and neuropeptides : Roles of orexins and orexin receptors. / Mieda, Michihiro; Yanagisawa, Masashi.

In: Current Opinion in Neurobiology, Vol. 12, No. 3, 01.06.2002, p. 339-345.

Research output: Contribution to journalArticle

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