Sleep, feeding, and neuropeptides: Roles of orexins and orexin receptors

Michihiro Mieda, Masashi Yanagisawa

Research output: Contribution to journalReview article

85 Scopus citations

Abstract

Recent studies using molecular genetics in mice and dogs, as well as histopathological analyses of human disease, have come to the same conclusion: the human sleep disorder narcolepsy is caused by failure of signaling mediated by orexin (hypocretin) neuropeptides. These and other findings strongly suggest that the orexin system plays a critical role in sleep/wake regulation. In addition, the orexin system may link energy homeostasis to the regulation of sleep/wake cycles.

Original languageEnglish (US)
Pages (from-to)339-345
Number of pages7
JournalCurrent Opinion in Neurobiology
Volume12
Issue number3
DOIs
StatePublished - Jun 1 2002

ASJC Scopus subject areas

  • Neuroscience(all)

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