TY - JOUR
T1 - Sleep, feeding, and neuropeptides
T2 - Roles of orexins and orexin receptors
AU - Mieda, Michihiro
AU - Yanagisawa, Masashi
PY - 2002/6/1
Y1 - 2002/6/1
N2 - Recent studies using molecular genetics in mice and dogs, as well as histopathological analyses of human disease, have come to the same conclusion: the human sleep disorder narcolepsy is caused by failure of signaling mediated by orexin (hypocretin) neuropeptides. These and other findings strongly suggest that the orexin system plays a critical role in sleep/wake regulation. In addition, the orexin system may link energy homeostasis to the regulation of sleep/wake cycles.
AB - Recent studies using molecular genetics in mice and dogs, as well as histopathological analyses of human disease, have come to the same conclusion: the human sleep disorder narcolepsy is caused by failure of signaling mediated by orexin (hypocretin) neuropeptides. These and other findings strongly suggest that the orexin system plays a critical role in sleep/wake regulation. In addition, the orexin system may link energy homeostasis to the regulation of sleep/wake cycles.
UR - http://www.scopus.com/inward/record.url?scp=0036606107&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0036606107&partnerID=8YFLogxK
U2 - 10.1016/S0959-4388(02)00331-8
DO - 10.1016/S0959-4388(02)00331-8
M3 - Review article
C2 - 12049942
AN - SCOPUS:0036606107
SN - 0959-4388
VL - 12
SP - 339
EP - 345
JO - Current Opinion in Neurobiology
JF - Current Opinion in Neurobiology
IS - 3
ER -