Sleep microarchitecture as a predictor of recurrence in children and adolescents with depression

Roseanne Armitage, Robert F. Hoffmann, Graham J. Emslie, Warren A. Weinberg, Taryn L. Mayes, A. John Rush

Research output: Contribution to journalArticle

27 Citations (Scopus)

Abstract

Although polysomnographic abnormalities are prevalent in adults with major depressive disorders (MDD), the findings in children and adolescents have been more equivocal. Polysomnographic measures may be of predictive value in assessing course of illness. The present study used standard sleep measures and temporal coherence of sleep electroencephalogram (EEG) rhythms to predict recovery and recurrence in a 1-yr naturalistic follow-up in 47 children and adolescents 8-18 yr of age with MDD. Standard sleep measures did not predict clinical course. On the other hand, temporal coherence measures discriminated between those who recovered, recovered but recurred, and those who did not recover from the index episode. Specifically, coherence between β, θ and δ recorded in the right hemisphere was significantly lower in the no-recovery group. In addition, temporal coherence was strongly associated with both time to recovery and recurrence. Those with the lowest coherence were less likely to recover or recurred sooner. Significant sex differences were found with a stronger relationship between temporal coherence and clinical course in boys. This study supports the use of quantitative sleep EEG measures as a predictor of clinical course in depression.

Original languageEnglish (US)
Pages (from-to)217-228
Number of pages12
JournalInternational Journal of Neuropsychopharmacology
Volume5
Issue number3
DOIs
StatePublished - Sep 2002

Fingerprint

Sleep
Depression
Recurrence
Major Depressive Disorder
Electroencephalography
Sex Characteristics

Keywords

  • Children
  • Depression
  • Recurrence
  • Sleep EEG

ASJC Scopus subject areas

  • Pharmacology (medical)
  • Neuropsychology and Physiological Psychology
  • Neuroscience(all)
  • Pharmacology, Toxicology and Pharmaceutics(all)

Cite this

Sleep microarchitecture as a predictor of recurrence in children and adolescents with depression. / Armitage, Roseanne; Hoffmann, Robert F.; Emslie, Graham J.; Weinberg, Warren A.; Mayes, Taryn L.; Rush, A. John.

In: International Journal of Neuropsychopharmacology, Vol. 5, No. 3, 09.2002, p. 217-228.

Research output: Contribution to journalArticle

Armitage, Roseanne ; Hoffmann, Robert F. ; Emslie, Graham J. ; Weinberg, Warren A. ; Mayes, Taryn L. ; Rush, A. John. / Sleep microarchitecture as a predictor of recurrence in children and adolescents with depression. In: International Journal of Neuropsychopharmacology. 2002 ; Vol. 5, No. 3. pp. 217-228.
@article{8f1e97fdf5ac46ae8d64af245bf272f0,
title = "Sleep microarchitecture as a predictor of recurrence in children and adolescents with depression",
abstract = "Although polysomnographic abnormalities are prevalent in adults with major depressive disorders (MDD), the findings in children and adolescents have been more equivocal. Polysomnographic measures may be of predictive value in assessing course of illness. The present study used standard sleep measures and temporal coherence of sleep electroencephalogram (EEG) rhythms to predict recovery and recurrence in a 1-yr naturalistic follow-up in 47 children and adolescents 8-18 yr of age with MDD. Standard sleep measures did not predict clinical course. On the other hand, temporal coherence measures discriminated between those who recovered, recovered but recurred, and those who did not recover from the index episode. Specifically, coherence between β, θ and δ recorded in the right hemisphere was significantly lower in the no-recovery group. In addition, temporal coherence was strongly associated with both time to recovery and recurrence. Those with the lowest coherence were less likely to recover or recurred sooner. Significant sex differences were found with a stronger relationship between temporal coherence and clinical course in boys. This study supports the use of quantitative sleep EEG measures as a predictor of clinical course in depression.",
keywords = "Children, Depression, Recurrence, Sleep EEG",
author = "Roseanne Armitage and Hoffmann, {Robert F.} and Emslie, {Graham J.} and Weinberg, {Warren A.} and Mayes, {Taryn L.} and Rush, {A. John}",
year = "2002",
month = "9",
doi = "10.1017/S1461145702002948",
language = "English (US)",
volume = "5",
pages = "217--228",
journal = "International Journal of Neuropsychopharmacology",
issn = "1461-1457",
publisher = "Cambridge University Press",
number = "3",

}

TY - JOUR

T1 - Sleep microarchitecture as a predictor of recurrence in children and adolescents with depression

AU - Armitage, Roseanne

AU - Hoffmann, Robert F.

AU - Emslie, Graham J.

AU - Weinberg, Warren A.

AU - Mayes, Taryn L.

AU - Rush, A. John

PY - 2002/9

Y1 - 2002/9

N2 - Although polysomnographic abnormalities are prevalent in adults with major depressive disorders (MDD), the findings in children and adolescents have been more equivocal. Polysomnographic measures may be of predictive value in assessing course of illness. The present study used standard sleep measures and temporal coherence of sleep electroencephalogram (EEG) rhythms to predict recovery and recurrence in a 1-yr naturalistic follow-up in 47 children and adolescents 8-18 yr of age with MDD. Standard sleep measures did not predict clinical course. On the other hand, temporal coherence measures discriminated between those who recovered, recovered but recurred, and those who did not recover from the index episode. Specifically, coherence between β, θ and δ recorded in the right hemisphere was significantly lower in the no-recovery group. In addition, temporal coherence was strongly associated with both time to recovery and recurrence. Those with the lowest coherence were less likely to recover or recurred sooner. Significant sex differences were found with a stronger relationship between temporal coherence and clinical course in boys. This study supports the use of quantitative sleep EEG measures as a predictor of clinical course in depression.

AB - Although polysomnographic abnormalities are prevalent in adults with major depressive disorders (MDD), the findings in children and adolescents have been more equivocal. Polysomnographic measures may be of predictive value in assessing course of illness. The present study used standard sleep measures and temporal coherence of sleep electroencephalogram (EEG) rhythms to predict recovery and recurrence in a 1-yr naturalistic follow-up in 47 children and adolescents 8-18 yr of age with MDD. Standard sleep measures did not predict clinical course. On the other hand, temporal coherence measures discriminated between those who recovered, recovered but recurred, and those who did not recover from the index episode. Specifically, coherence between β, θ and δ recorded in the right hemisphere was significantly lower in the no-recovery group. In addition, temporal coherence was strongly associated with both time to recovery and recurrence. Those with the lowest coherence were less likely to recover or recurred sooner. Significant sex differences were found with a stronger relationship between temporal coherence and clinical course in boys. This study supports the use of quantitative sleep EEG measures as a predictor of clinical course in depression.

KW - Children

KW - Depression

KW - Recurrence

KW - Sleep EEG

UR - http://www.scopus.com/inward/record.url?scp=0036735039&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0036735039&partnerID=8YFLogxK

U2 - 10.1017/S1461145702002948

DO - 10.1017/S1461145702002948

M3 - Article

C2 - 12366874

AN - SCOPUS:0036735039

VL - 5

SP - 217

EP - 228

JO - International Journal of Neuropsychopharmacology

JF - International Journal of Neuropsychopharmacology

SN - 1461-1457

IS - 3

ER -