TY - JOUR
T1 - Sleeping Sickness
T2 - A Tale of Two Clocks
AU - Rijo-Ferreira, Filipa
AU - Takahashi, Joseph S.
N1 - Funding Information:
We are most grateful to Fernando Augusto (https://made-for.studio) for the design of the figures and Kimberly Cox for critical reading and proofreading of the manuscript. Apologies to those whose work was not cited because of content and length constraints. Funding. The authors would like to thank the support of the funding agencies, NIGMS K99GM132557 awarded to FR-F and Howard Hughes Medical Institute. JST is an Investigator and FR-F is an Associate in the Howard Hughes Medical Institute.
Publisher Copyright:
© Copyright © 2020 Rijo-Ferreira and Takahashi.
PY - 2020/10/2
Y1 - 2020/10/2
N2 - Sleeping sickness is caused by a eukaryotic unicellular parasite known to infect wild animals, cattle, and humans. It causes a fatal disease that disrupts many rhythmic physiological processes, including daily rhythms of hormonal secretion, temperature regulation, and sleep, all of which are under circadian (24-h) control. In this review, we summarize research on sleeping sickness parasite biology and the impact it has on host health. We also consider the possible evolutionary advantages of sleep and circadian deregulation for the parasite.
AB - Sleeping sickness is caused by a eukaryotic unicellular parasite known to infect wild animals, cattle, and humans. It causes a fatal disease that disrupts many rhythmic physiological processes, including daily rhythms of hormonal secretion, temperature regulation, and sleep, all of which are under circadian (24-h) control. In this review, we summarize research on sleeping sickness parasite biology and the impact it has on host health. We also consider the possible evolutionary advantages of sleep and circadian deregulation for the parasite.
KW - circadial rhythm disorders
KW - circadian
KW - infectious disease
KW - parasite
KW - sleep
UR - http://www.scopus.com/inward/record.url?scp=85092928929&partnerID=8YFLogxK
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U2 - 10.3389/fcimb.2020.525097
DO - 10.3389/fcimb.2020.525097
M3 - Review article
C2 - 33134186
AN - SCOPUS:85092928929
SN - 2235-2988
VL - 10
JO - Frontiers in Cellular and Infection Microbiology
JF - Frontiers in Cellular and Infection Microbiology
M1 - 525097
ER -