Sleeping sickness is a circadian disorder

Filipa Rijo-Ferreira, Tânia Carvalho, Cristina Afonso, Margarida Sanches-Vaz, Rui M. Costa, Luísa M. Figueiredo, Joseph S. Takahashi

Research output: Contribution to journalArticle

20 Citations (Scopus)

Abstract

Sleeping sickness is a fatal disease caused by Trypanosoma brucei, a unicellular parasite that lives in the bloodstream and interstitial spaces of peripheral tissues and the brain. Patients have altered sleep/wake cycles, body temperature, and endocrine profiles, but the underlying causes are unknown. Here, we show that the robust circadian rhythms of mice become phase advanced upon infection, with abnormal activity occurring during the rest phase. This advanced phase is caused by shortening of the circadian period both at the behavioral level as well as at the tissue and cell level. Period shortening is T. brucei specific and independent of the host immune response, as co-culturing parasites with explants or fibroblasts also shortens the clock period, whereas malaria infection does not. We propose that T. brucei causes an advanced circadian rhythm disorder, previously associated only with mutations in clock genes, which leads to changes in the timing of sleep.

Original languageEnglish (US)
Article number02484
JournalNature Communications
Volume9
Issue number1
DOIs
StatePublished - Dec 1 2018

Fingerprint

sicknesses
circadian rhythms
parasites
sleep
Trypanosoma brucei brucei
infectious diseases
clocks
Clocks
disorders
Tissue
body temperature
causes
Sleep
fibroblasts
Chronobiology Disorders
Parasites
Fibroblasts
mutations
wakes
genes

ASJC Scopus subject areas

  • Chemistry(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Physics and Astronomy(all)

Cite this

Rijo-Ferreira, F., Carvalho, T., Afonso, C., Sanches-Vaz, M., Costa, R. M., Figueiredo, L. M., & Takahashi, J. S. (2018). Sleeping sickness is a circadian disorder. Nature Communications, 9(1), [02484]. https://doi.org/10.1038/s41467-017-02484-2

Sleeping sickness is a circadian disorder. / Rijo-Ferreira, Filipa; Carvalho, Tânia; Afonso, Cristina; Sanches-Vaz, Margarida; Costa, Rui M.; Figueiredo, Luísa M.; Takahashi, Joseph S.

In: Nature Communications, Vol. 9, No. 1, 02484, 01.12.2018.

Research output: Contribution to journalArticle

Rijo-Ferreira, F, Carvalho, T, Afonso, C, Sanches-Vaz, M, Costa, RM, Figueiredo, LM & Takahashi, JS 2018, 'Sleeping sickness is a circadian disorder', Nature Communications, vol. 9, no. 1, 02484. https://doi.org/10.1038/s41467-017-02484-2
Rijo-Ferreira F, Carvalho T, Afonso C, Sanches-Vaz M, Costa RM, Figueiredo LM et al. Sleeping sickness is a circadian disorder. Nature Communications. 2018 Dec 1;9(1). 02484. https://doi.org/10.1038/s41467-017-02484-2
Rijo-Ferreira, Filipa ; Carvalho, Tânia ; Afonso, Cristina ; Sanches-Vaz, Margarida ; Costa, Rui M. ; Figueiredo, Luísa M. ; Takahashi, Joseph S. / Sleeping sickness is a circadian disorder. In: Nature Communications. 2018 ; Vol. 9, No. 1.
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