TY - JOUR
T1 - Slice-to-volume registration and its potential application to interventional MRI-guided radio-frequency thermal ablation of prostate cancer
AU - Fei, Baowei
AU - Duerk, Jeffrey L.
AU - Boll, Daniel T.
AU - Lewin, Jonathan S.
AU - Wilson, David L.
N1 - Funding Information:
Manuscript received August 20, 2002; revised November 10, 2002. The algorithm developed in this research was supported by the National Institutes of Health (NIH) under Grant R01-CA84433-01 to D. L. Wilson and by the Department of Defense under Grant DAMD17-02-1-0230 to B. W. Fei. Imaging techniques were developed under the support of the NIH under Grant R33-CA88144-01 to J. L. Duerk. The Associate Editor responsible for coordinating the review of this paper and recommending its publication was W. Niessen. Asterisk indicates corresponding author.
PY - 2003/4
Y1 - 2003/4
N2 - In this study, we registered live-time interventional magnetic resonance imaging (iMRI) slices with a previously obtained high-resolution MRI volume that in turn can be registered with a variety of functional images, e.g., PET, SPECT, for tumor targeting. We created and evaluated a slice-to-volume (SV) registration algorithm with special features for its potential use in iMRI-guided radio-frequency (RF) thermal ablation of prostate cancer. The algorithm features included a multiresolution approach, two similarity measures, and automatic restarting to avoid local minima. Imaging experiments were performed on volunteers using a conventional 1.5-T MR scanner and a clinical 0.2-T C-arm iMRI system under realistic conditions. Both high-resolution MR volumes and actual iMRI image slices were acquired from the same volunteers. Actual and simulated iMRI images were used to test the dependence of SV registration on image noise, receive coil inhomogeneity, and RF needle artifacts. To quantitatively assess registration, we calculated the mean voxel displacement over a volume of interest between SV registration and volume-to-volume registration, which was previously shown to be quite accurate. More than 800 registration experiments were performed. For transverse image slices covering the prostate, the SV registration algorithm was 100% successful with an error of <2 mm, and the average and standard deviation was only 0.4 mm ± 0.2 mm. Visualizations such as combined sector display and contour overlay showed excellent registration of the prostate and other organs throughout the pelvis. Error was greater when an image slice was obtained at other orientations and positions, mostly because of inconsistent image content such as that from variable rectal and bladder filling. These preliminary experiments indicate that MR SV registration is sufficient accurate to aid image-guided therapy.
AB - In this study, we registered live-time interventional magnetic resonance imaging (iMRI) slices with a previously obtained high-resolution MRI volume that in turn can be registered with a variety of functional images, e.g., PET, SPECT, for tumor targeting. We created and evaluated a slice-to-volume (SV) registration algorithm with special features for its potential use in iMRI-guided radio-frequency (RF) thermal ablation of prostate cancer. The algorithm features included a multiresolution approach, two similarity measures, and automatic restarting to avoid local minima. Imaging experiments were performed on volunteers using a conventional 1.5-T MR scanner and a clinical 0.2-T C-arm iMRI system under realistic conditions. Both high-resolution MR volumes and actual iMRI image slices were acquired from the same volunteers. Actual and simulated iMRI images were used to test the dependence of SV registration on image noise, receive coil inhomogeneity, and RF needle artifacts. To quantitatively assess registration, we calculated the mean voxel displacement over a volume of interest between SV registration and volume-to-volume registration, which was previously shown to be quite accurate. More than 800 registration experiments were performed. For transverse image slices covering the prostate, the SV registration algorithm was 100% successful with an error of <2 mm, and the average and standard deviation was only 0.4 mm ± 0.2 mm. Visualizations such as combined sector display and contour overlay showed excellent registration of the prostate and other organs throughout the pelvis. Error was greater when an image slice was obtained at other orientations and positions, mostly because of inconsistent image content such as that from variable rectal and bladder filling. These preliminary experiments indicate that MR SV registration is sufficient accurate to aid image-guided therapy.
KW - Image registration
KW - Interventional magnetic resonance imaging (iMRI)
KW - Minimally invasive treatment
KW - Mutual information
KW - Prostate cancer
KW - Thermal ablation
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U2 - 10.1109/TMI.2003.809078
DO - 10.1109/TMI.2003.809078
M3 - Article
C2 - 12774897
AN - SCOPUS:0038278916
SN - 0278-0062
VL - 22
SP - 515
EP - 525
JO - IEEE Transactions on Medical Imaging
JF - IEEE Transactions on Medical Imaging
IS - 4
ER -