Slow-wave activity during non-REM sleep in men with schizophrenia and major depressive disorders

Robert Hoffmann, William Hendrickse, A. John Rush, Roseanne Armitage

Research output: Contribution to journalArticle

66 Citations (Scopus)

Abstract

Both major depressive disorders (MDD) and schizophrenia (SZ) have been associated with reductions in slow-wave (Stages 3 and 4) sleep, although these findings are controversial. The present study compared quantitative EEG measures of slow-wave activity (0.5-4 Hz) during non-REM (NREM) sleep among age-matched, symptomatic but unmedicated, depressed, schizophrenic and healthy control men (n = 13/group). The amplitude of slow-wave activity (SWA) in the first NREM sleep period was significantly lower in both the MDD and SZ groups compared with controls. However, the time course of SWA, its accumulation and dissipation over all NREM sleep time, was abnormal in the MDD group but not in those with SZ. These findings suggest that the regulation of SWA is impaired in men with MDD but not in SZ. Thus, although those with SZ show reduced amplitude SWA in the first NREM period, there is no evidence that homeostatic regulation of SWA is impaired in this psychiatric group. (C) 2000 Elsevier Science Ireland Ltd.

Original languageEnglish (US)
Pages (from-to)215-225
Number of pages11
JournalPsychiatry Research
Volume95
Issue number3
DOIs
StatePublished - Jul 11 2000

Fingerprint

Major Depressive Disorder
Schizophrenia
Sleep
Psychiatry
Electroencephalography

Keywords

  • Delta
  • Depression
  • Polysomnography
  • Schizophrenia
  • Sleep

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Biological Psychiatry
  • Psychology(all)

Cite this

Slow-wave activity during non-REM sleep in men with schizophrenia and major depressive disorders. / Hoffmann, Robert; Hendrickse, William; Rush, A. John; Armitage, Roseanne.

In: Psychiatry Research, Vol. 95, No. 3, 11.07.2000, p. 215-225.

Research output: Contribution to journalArticle

Hoffmann, Robert ; Hendrickse, William ; Rush, A. John ; Armitage, Roseanne. / Slow-wave activity during non-REM sleep in men with schizophrenia and major depressive disorders. In: Psychiatry Research. 2000 ; Vol. 95, No. 3. pp. 215-225.
@article{e509939d395e4ffaa45178501920af96,
title = "Slow-wave activity during non-REM sleep in men with schizophrenia and major depressive disorders",
abstract = "Both major depressive disorders (MDD) and schizophrenia (SZ) have been associated with reductions in slow-wave (Stages 3 and 4) sleep, although these findings are controversial. The present study compared quantitative EEG measures of slow-wave activity (0.5-4 Hz) during non-REM (NREM) sleep among age-matched, symptomatic but unmedicated, depressed, schizophrenic and healthy control men (n = 13/group). The amplitude of slow-wave activity (SWA) in the first NREM sleep period was significantly lower in both the MDD and SZ groups compared with controls. However, the time course of SWA, its accumulation and dissipation over all NREM sleep time, was abnormal in the MDD group but not in those with SZ. These findings suggest that the regulation of SWA is impaired in men with MDD but not in SZ. Thus, although those with SZ show reduced amplitude SWA in the first NREM period, there is no evidence that homeostatic regulation of SWA is impaired in this psychiatric group. (C) 2000 Elsevier Science Ireland Ltd.",
keywords = "Delta, Depression, Polysomnography, Schizophrenia, Sleep",
author = "Robert Hoffmann and William Hendrickse and Rush, {A. John} and Roseanne Armitage",
year = "2000",
month = "7",
day = "11",
doi = "10.1016/S0165-1781(00)00181-5",
language = "English (US)",
volume = "95",
pages = "215--225",
journal = "Psychiatry Research",
issn = "0165-1781",
publisher = "Elsevier Ireland Ltd",
number = "3",

}

TY - JOUR

T1 - Slow-wave activity during non-REM sleep in men with schizophrenia and major depressive disorders

AU - Hoffmann, Robert

AU - Hendrickse, William

AU - Rush, A. John

AU - Armitage, Roseanne

PY - 2000/7/11

Y1 - 2000/7/11

N2 - Both major depressive disorders (MDD) and schizophrenia (SZ) have been associated with reductions in slow-wave (Stages 3 and 4) sleep, although these findings are controversial. The present study compared quantitative EEG measures of slow-wave activity (0.5-4 Hz) during non-REM (NREM) sleep among age-matched, symptomatic but unmedicated, depressed, schizophrenic and healthy control men (n = 13/group). The amplitude of slow-wave activity (SWA) in the first NREM sleep period was significantly lower in both the MDD and SZ groups compared with controls. However, the time course of SWA, its accumulation and dissipation over all NREM sleep time, was abnormal in the MDD group but not in those with SZ. These findings suggest that the regulation of SWA is impaired in men with MDD but not in SZ. Thus, although those with SZ show reduced amplitude SWA in the first NREM period, there is no evidence that homeostatic regulation of SWA is impaired in this psychiatric group. (C) 2000 Elsevier Science Ireland Ltd.

AB - Both major depressive disorders (MDD) and schizophrenia (SZ) have been associated with reductions in slow-wave (Stages 3 and 4) sleep, although these findings are controversial. The present study compared quantitative EEG measures of slow-wave activity (0.5-4 Hz) during non-REM (NREM) sleep among age-matched, symptomatic but unmedicated, depressed, schizophrenic and healthy control men (n = 13/group). The amplitude of slow-wave activity (SWA) in the first NREM sleep period was significantly lower in both the MDD and SZ groups compared with controls. However, the time course of SWA, its accumulation and dissipation over all NREM sleep time, was abnormal in the MDD group but not in those with SZ. These findings suggest that the regulation of SWA is impaired in men with MDD but not in SZ. Thus, although those with SZ show reduced amplitude SWA in the first NREM period, there is no evidence that homeostatic regulation of SWA is impaired in this psychiatric group. (C) 2000 Elsevier Science Ireland Ltd.

KW - Delta

KW - Depression

KW - Polysomnography

KW - Schizophrenia

KW - Sleep

UR - http://www.scopus.com/inward/record.url?scp=0034636692&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0034636692&partnerID=8YFLogxK

U2 - 10.1016/S0165-1781(00)00181-5

DO - 10.1016/S0165-1781(00)00181-5

M3 - Article

C2 - 10974360

AN - SCOPUS:0034636692

VL - 95

SP - 215

EP - 225

JO - Psychiatry Research

JF - Psychiatry Research

SN - 0165-1781

IS - 3

ER -