Small cell lung cancer 1973-1983

Early progress and recent obstacles

George Morstyn, Daniel C. Ihde, Allen S. Lichter, Paul A. Bunn, Desmond N. Carney, Eli Glatstein, John D. Minna

Research output: Contribution to journalArticle

157 Citations (Scopus)

Abstract

The recognition that the vast majority of patients with small cell lung cancer have distant metastatic disease at the time of diagnosis led to the use of systemic chemotherapy and consequent major improvements in survival in the early to mid-1970's. In the past five years, however, the pace of therapeutic advances has slowed. Recently evaluated treatment strategies, including more intensive induction chemotherapy, "late intensive' therapy of responding patients, alternation of chemotherapeutic regimens, integration of chest irradiation with drug therapy, large field irradiation, and reappraisal of the value of surgical resection, are discussed in this review. Advances in understanding of the cell biology of small cell lung cancer which may eventually lead to new forms of treatment are summarized.

Original languageEnglish (US)
Pages (from-to)515-539
Number of pages25
JournalInternational Journal of Radiation Oncology, Biology, Physics
Volume10
Issue number4
DOIs
StatePublished - 1984

Fingerprint

Small Cell Lung Carcinoma
chemotherapy
lungs
cancer
irradiation
chest
alternations
Drug Therapy
Induction Chemotherapy
therapy
induction
Therapeutics
Cell Biology
Thorax
Survival

Keywords

  • Cell biology of small cell lung cancer
  • Chemotherapeutic agents
  • Chemotherapeutic strategy in small cell lung cancer, Thoracic irradiation
  • Cranial irradiation
  • Lung neoplasms, small cell
  • Wide field irradiation

ASJC Scopus subject areas

  • Oncology
  • Radiology Nuclear Medicine and imaging
  • Radiation

Cite this

Small cell lung cancer 1973-1983 : Early progress and recent obstacles. / Morstyn, George; Ihde, Daniel C.; Lichter, Allen S.; Bunn, Paul A.; Carney, Desmond N.; Glatstein, Eli; Minna, John D.

In: International Journal of Radiation Oncology, Biology, Physics, Vol. 10, No. 4, 1984, p. 515-539.

Research output: Contribution to journalArticle

Morstyn, George ; Ihde, Daniel C. ; Lichter, Allen S. ; Bunn, Paul A. ; Carney, Desmond N. ; Glatstein, Eli ; Minna, John D. / Small cell lung cancer 1973-1983 : Early progress and recent obstacles. In: International Journal of Radiation Oncology, Biology, Physics. 1984 ; Vol. 10, No. 4. pp. 515-539.
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