Small fiber neuropathy: A burning problem

Jinny Tavee, Lan Zhou

Research output: Contribution to journalReview articlepeer-review

125 Scopus citations

Abstract

Small fiber neuropathy is increasingly being recognized as a major cause of painful burning sensations in the feet, especially in the elderly. Although strength remains preserved throughout the course of the disease, the pain and paresthesias are often disabling. Diabetes mellitus is the most common identifiable cause of small fiber neuropathy, and impaired oral glucose tolerance and individual components of the metabolic syndrome are often associated with it. Some cases, however, are idiopathic. Skin biopsy (with an evaluation of the density of intraepidermal nerve fibers) and tests of autonomic nerve function are useful for the diagnosis. Management involves controlling pain and identifying and aggressively treating the underlying cause.

Original languageEnglish (US)
Pages (from-to)297-305
Number of pages9
JournalCleveland Clinic journal of medicine
Volume76
Issue number5
DOIs
StatePublished - May 1 2009

ASJC Scopus subject areas

  • Medicine(all)

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