Small-molecule activation of neuronal cell fate

Jay W Schneider, Zhengliang Gao, Shijie Li, Midhat Farooqi, Tie Shan Tang, Ilya Bezprozvanny, Doug E. Frantz, Jenny Hsieh

Research output: Contribution to journalArticle

104 Scopus citations

Abstract

We probed an epigenetic regulatory path from small molecule to neuronal gene activation. Isoxazole small molecules triggered robust neuronal differentiation in adult neural stem cells, rapidly signaling to the neuronal genome via Ca2+ influx. Ca2+-activated CaMK phosphorylated and mediated nuclear export of the MEF2 regulator HDAC5, thereby de-repressing neuronal genes. These results provide new tools to explore the epigenetic signaling circuitry specifying neuronal cell fate and new leads for neuro-regenerative drugs.

Original languageEnglish (US)
Pages (from-to)408-410
Number of pages3
JournalNature chemical biology
Volume4
Issue number7
DOIs
StatePublished - Jul 2008

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ASJC Scopus subject areas

  • Molecular Biology
  • Cell Biology

Cite this

Schneider, J. W., Gao, Z., Li, S., Farooqi, M., Tang, T. S., Bezprozvanny, I., Frantz, D. E., & Hsieh, J. (2008). Small-molecule activation of neuronal cell fate. Nature chemical biology, 4(7), 408-410. https://doi.org/10.1038/nchembio.95