Small molecule modifiers of circadian clocks

Zheng Chen, Seung Hee Yoo, Joseph S. Takahashi

Research output: Contribution to journalArticle

51 Citations (Scopus)

Abstract

Circadian clocks orchestrate 24-h oscillations of essential physiological and behavioral processes in response to daily environmental changes. These clocks are remarkably precise under constant conditions yet highly responsive to resetting signals. With the molecular composition of the core oscillator largely established, recent research has increasingly focused on clock-modifying mechanisms/molecules. In particular, small molecule modifiers, intrinsic or extrinsic, are emerging as powerful tools for understanding basic clock biology as well as developing putative therapeutic agents for clock-associated diseases. In this review, we will focus on synthetic compounds capable of modifying the period, phase, or amplitude of circadian clocks, with particular emphasis on the mammalian clock. We will discuss the potential of exploiting these small molecule modifiers in both basic and translational research.

Original languageEnglish (US)
Pages (from-to)2985-2998
Number of pages14
JournalCellular and Molecular Life Sciences
Volume70
Issue number16
DOIs
StatePublished - Aug 2013

Fingerprint

Circadian Clocks
Physiological Phenomena
Translational Medical Research
Research
Therapeutics

Keywords

  • Amplitude
  • Chronotherapy
  • Clock-associated diseases
  • Metabolites
  • Period
  • Phase
  • Synthetic compounds

ASJC Scopus subject areas

  • Cell Biology
  • Molecular Biology
  • Molecular Medicine
  • Pharmacology
  • Cellular and Molecular Neuroscience

Cite this

Small molecule modifiers of circadian clocks. / Chen, Zheng; Yoo, Seung Hee; Takahashi, Joseph S.

In: Cellular and Molecular Life Sciences, Vol. 70, No. 16, 08.2013, p. 2985-2998.

Research output: Contribution to journalArticle

Chen, Zheng ; Yoo, Seung Hee ; Takahashi, Joseph S. / Small molecule modifiers of circadian clocks. In: Cellular and Molecular Life Sciences. 2013 ; Vol. 70, No. 16. pp. 2985-2998.
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