Small Molecules, Big Effects: A Role for Chromatin-Localized Metabolite Biosynthesis in Gene Regulation

Bryan A. Gibson, W. Lee Kraus

Research output: Contribution to journalShort survey

12 Scopus citations

Abstract

In this issue of Molecular Cell, Katoh et al. (2011) show that the biosynthetic enzyme MATIIα binds at the HO-1 locus in mammalian cells and exhibits transcriptional corepressor activity through local production of S-adenosylmethionine, which stimulates histone methyltransferases to promote a transcriptionally repressive chromatin environment.

Original languageEnglish (US)
Pages (from-to)497-499
Number of pages3
JournalMolecular cell
Volume41
Issue number5
DOIs
StatePublished - Mar 4 2011

ASJC Scopus subject areas

  • Molecular Biology
  • Cell Biology

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