SmI2 mediated reductive addition of bis-phenylsulfones to ketones

S. Chandrasekhar; Jurong Yu; J R Falck; C. Mioskowski

doi:10.1016/S0040-4039(00)73520-9

SmI₂ mediated reductive addition of bis-phenylsulfones to ketones

S. Chandrasekhar, Jurong Yu, J R Falck, C. Mioskowski

Biochemistry

Research output: Contribution to journal › Article › peer-review

23 Scopus citations

Abstract

SmI₂ mediates the in situ reductive addition of geminal bis-phenylsulfones to unhindered ketones at room temperature affording β-hydroxyphenylsulfones in good to excellent yields.

Original language	English (US)
Pages (from-to)	5441-5444
Number of pages	4
Journal	Tetrahedron Letters
Volume	35
Issue number	30
DOIs	https://doi.org/10.1016/S0040-4039(00)73520-9
State	Published - Jul 25 1994

Keywords

alkylation
desulfonylation
diiodosamarium
β-hydroxyphenylsulfone

ASJC Scopus subject areas

Biochemistry
Drug Discovery
Organic Chemistry

Access to Document

10.1016/S0040-4039(00)73520-9

Cite this

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title = "SmI2 mediated reductive addition of bis-phenylsulfones to ketones",

abstract = "SmI2 mediates the in situ reductive addition of geminal bis-phenylsulfones to unhindered ketones at room temperature affording β-hydroxyphenylsulfones in good to excellent yields.",

keywords = "alkylation, desulfonylation, diiodosamarium, β-hydroxyphenylsulfone",

author = "S. Chandrasekhar and Jurong Yu and Falck, {J R} and C. Mioskowski",

note = "Funding Information: Supported financially by the USPHS NIH (D&38226)",

year = "1994",

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T1 - SmI2 mediated reductive addition of bis-phenylsulfones to ketones

AU - Chandrasekhar, S.

AU - Yu, Jurong

AU - Falck, J R

AU - Mioskowski, C.

N1 - Funding Information: Supported financially by the USPHS NIH (D&38226)

PY - 1994/7/25

Y1 - 1994/7/25

N2 - SmI2 mediates the in situ reductive addition of geminal bis-phenylsulfones to unhindered ketones at room temperature affording β-hydroxyphenylsulfones in good to excellent yields.

AB - SmI2 mediates the in situ reductive addition of geminal bis-phenylsulfones to unhindered ketones at room temperature affording β-hydroxyphenylsulfones in good to excellent yields.

KW - alkylation

KW - desulfonylation

KW - diiodosamarium

KW - β-hydroxyphenylsulfone

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