Smoking molecular damage in bronchial epithelium

Ignacio I. Wistuba, Li Mao, Adi F. Gazdar

Research output: Contribution to journalArticle

125 Citations (Scopus)

Abstract

Our understanding of the molecular pathology of lung cancer is advancing rapidly with several specific genes and chromosomal regions being identified. Lung cancer appears to require many mutations in both dominant and recessive oncogenes to possess malignant phenotypes. Several genetic and epigenetic changes are common to all lung cancer histologic types, while others appear to be cell type specific. However, specific roles of the genes undergoing mutations and the order of cumulative molecular changes that lead to the development of each lung tumor histologic type remain to be fully elucidated. Recent findings of molecular abnormalities in normal appearing and preneoplastic bronchial epithelium from patients with lung cancer and chronic smokers suggest that genetic changes may serve as biomarkers for early diagnosis, risk assessment and monitoring response to chemoprevention.

Original languageEnglish (US)
Pages (from-to)7298-7306
Number of pages9
JournalOncogene
Volume21
Issue number48 REV. ISS. 6
DOIs
StatePublished - Oct 21 2002

Fingerprint

Lung Neoplasms
Epithelium
Smoking
Mutation
Molecular Pathology
Chemoprevention
Tumor Suppressor Genes
Epigenomics
Genes
Early Diagnosis
Biomarkers
Phenotype
Lung
Neoplasms

Keywords

  • Lung cancer
  • Preneoplasia
  • Smoking

ASJC Scopus subject areas

  • Molecular Biology
  • Cancer Research
  • Genetics

Cite this

Smoking molecular damage in bronchial epithelium. / Wistuba, Ignacio I.; Mao, Li; Gazdar, Adi F.

In: Oncogene, Vol. 21, No. 48 REV. ISS. 6, 21.10.2002, p. 7298-7306.

Research output: Contribution to journalArticle

Wistuba, II, Mao, L & Gazdar, AF 2002, 'Smoking molecular damage in bronchial epithelium', Oncogene, vol. 21, no. 48 REV. ISS. 6, pp. 7298-7306. https://doi.org/10.1038/sj.onc.1205806
Wistuba, Ignacio I. ; Mao, Li ; Gazdar, Adi F. / Smoking molecular damage in bronchial epithelium. In: Oncogene. 2002 ; Vol. 21, No. 48 REV. ISS. 6. pp. 7298-7306.
@article{19db051174d54c38bbaed3bd11aafbec,
title = "Smoking molecular damage in bronchial epithelium",
abstract = "Our understanding of the molecular pathology of lung cancer is advancing rapidly with several specific genes and chromosomal regions being identified. Lung cancer appears to require many mutations in both dominant and recessive oncogenes to possess malignant phenotypes. Several genetic and epigenetic changes are common to all lung cancer histologic types, while others appear to be cell type specific. However, specific roles of the genes undergoing mutations and the order of cumulative molecular changes that lead to the development of each lung tumor histologic type remain to be fully elucidated. Recent findings of molecular abnormalities in normal appearing and preneoplastic bronchial epithelium from patients with lung cancer and chronic smokers suggest that genetic changes may serve as biomarkers for early diagnosis, risk assessment and monitoring response to chemoprevention.",
keywords = "Lung cancer, Preneoplasia, Smoking",
author = "Wistuba, {Ignacio I.} and Li Mao and Gazdar, {Adi F.}",
year = "2002",
month = "10",
day = "21",
doi = "10.1038/sj.onc.1205806",
language = "English (US)",
volume = "21",
pages = "7298--7306",
journal = "Oncogene",
issn = "0950-9232",
publisher = "Nature Publishing Group",
number = "48 REV. ISS. 6",

}

TY - JOUR

T1 - Smoking molecular damage in bronchial epithelium

AU - Wistuba, Ignacio I.

AU - Mao, Li

AU - Gazdar, Adi F.

PY - 2002/10/21

Y1 - 2002/10/21

N2 - Our understanding of the molecular pathology of lung cancer is advancing rapidly with several specific genes and chromosomal regions being identified. Lung cancer appears to require many mutations in both dominant and recessive oncogenes to possess malignant phenotypes. Several genetic and epigenetic changes are common to all lung cancer histologic types, while others appear to be cell type specific. However, specific roles of the genes undergoing mutations and the order of cumulative molecular changes that lead to the development of each lung tumor histologic type remain to be fully elucidated. Recent findings of molecular abnormalities in normal appearing and preneoplastic bronchial epithelium from patients with lung cancer and chronic smokers suggest that genetic changes may serve as biomarkers for early diagnosis, risk assessment and monitoring response to chemoprevention.

AB - Our understanding of the molecular pathology of lung cancer is advancing rapidly with several specific genes and chromosomal regions being identified. Lung cancer appears to require many mutations in both dominant and recessive oncogenes to possess malignant phenotypes. Several genetic and epigenetic changes are common to all lung cancer histologic types, while others appear to be cell type specific. However, specific roles of the genes undergoing mutations and the order of cumulative molecular changes that lead to the development of each lung tumor histologic type remain to be fully elucidated. Recent findings of molecular abnormalities in normal appearing and preneoplastic bronchial epithelium from patients with lung cancer and chronic smokers suggest that genetic changes may serve as biomarkers for early diagnosis, risk assessment and monitoring response to chemoprevention.

KW - Lung cancer

KW - Preneoplasia

KW - Smoking

UR - http://www.scopus.com/inward/record.url?scp=0037152658&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0037152658&partnerID=8YFLogxK

U2 - 10.1038/sj.onc.1205806

DO - 10.1038/sj.onc.1205806

M3 - Article

VL - 21

SP - 7298

EP - 7306

JO - Oncogene

JF - Oncogene

SN - 0950-9232

IS - 48 REV. ISS. 6

ER -