Smoking molecular damage in bronchial epithelium

Ignacio I. Wistuba, Li Mao, Adi F. Gazdar

Research output: Contribution to journalArticle

126 Scopus citations

Abstract

Our understanding of the molecular pathology of lung cancer is advancing rapidly with several specific genes and chromosomal regions being identified. Lung cancer appears to require many mutations in both dominant and recessive oncogenes to possess malignant phenotypes. Several genetic and epigenetic changes are common to all lung cancer histologic types, while others appear to be cell type specific. However, specific roles of the genes undergoing mutations and the order of cumulative molecular changes that lead to the development of each lung tumor histologic type remain to be fully elucidated. Recent findings of molecular abnormalities in normal appearing and preneoplastic bronchial epithelium from patients with lung cancer and chronic smokers suggest that genetic changes may serve as biomarkers for early diagnosis, risk assessment and monitoring response to chemoprevention.

Original languageEnglish (US)
Pages (from-to)7298-7306
Number of pages9
JournalOncogene
Volume21
Issue number6
DOIs
StatePublished - Oct 21 2002

Keywords

  • Lung cancer
  • Preneoplasia
  • Smoking

ASJC Scopus subject areas

  • Molecular Biology
  • Genetics
  • Cancer Research

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    Wistuba, I. I., Mao, L., & Gazdar, A. F. (2002). Smoking molecular damage in bronchial epithelium. Oncogene, 21(6), 7298-7306. https://doi.org/10.1038/sj.onc.1205806