Snares and munc18 in synaptic vesicle fusion

Jose Rizo-Rey, Thomas C. Südhof

Research output: Contribution to journalArticle

400 Citations (Scopus)

Abstract

The release of neurotransmitters by Ca2+-triggered synaptic vesicle exocytosis is an exquisitely regulated process that is fundamental for interneuronal communication. This process involves several steps and is controlled by a protein machinery that must prevent release before Ca2+ entry into presynaptic terminals, and yet must rapidly induce release on Ca2+ influx. Extensive studies of the components of this machinery have indicated that SNAREs and Munc 18-1 are central proteins for membrane fusion during exocytosis. An increasing amount of information derived from a convergence of structural, physiological and genetic studies is providing important insights into the mechanism of neurotransmitter release.

Original languageEnglish (US)
Pages (from-to)641-653
Number of pages13
JournalNature Reviews Neuroscience
Volume3
Issue number8
StatePublished - Aug 2002

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Synaptic Vesicles
Exocytosis
Neurotransmitter Agents
Membrane Fusion Proteins
SNARE Proteins
Presynaptic Terminals
Proteins

ASJC Scopus subject areas

  • Cell Biology
  • Neuroscience(all)

Cite this

Snares and munc18 in synaptic vesicle fusion. / Rizo-Rey, Jose; Südhof, Thomas C.

In: Nature Reviews Neuroscience, Vol. 3, No. 8, 08.2002, p. 641-653.

Research output: Contribution to journalArticle

Rizo-Rey, Jose ; Südhof, Thomas C. / Snares and munc18 in synaptic vesicle fusion. In: Nature Reviews Neuroscience. 2002 ; Vol. 3, No. 8. pp. 641-653.
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