Snares and munc18 in synaptic vesicle fusion

Jose Rizo-Rey, Thomas C. Südhof

Research output: Contribution to journalReview article

403 Scopus citations

Abstract

The release of neurotransmitters by Ca2+-triggered synaptic vesicle exocytosis is an exquisitely regulated process that is fundamental for interneuronal communication. This process involves several steps and is controlled by a protein machinery that must prevent release before Ca2+ entry into presynaptic terminals, and yet must rapidly induce release on Ca2+ influx. Extensive studies of the components of this machinery have indicated that SNAREs and Munc 18-1 are central proteins for membrane fusion during exocytosis. An increasing amount of information derived from a convergence of structural, physiological and genetic studies is providing important insights into the mechanism of neurotransmitter release.

Original languageEnglish (US)
Pages (from-to)641-653
Number of pages13
JournalNature Reviews Neuroscience
Volume3
Issue number8
DOIs
StatePublished - Aug 2002

ASJC Scopus subject areas

  • Neuroscience(all)

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