Sodium channels gone wild

Resurgent current from neuronal and muscle channelopathies

Stephen C. Cannon, Bruce P. Bean

Research output: Contribution to journalArticle

16 Citations (Scopus)

Abstract

Voltage-dependent sodium channels are the central players in the excitability of neurons, cardiac muscle, and skeletal muscle. Hundreds of mutations in sodium channels have been associated with human disease, particularly genetic forms of epilepsy, arrhythmias, myotonia, and periodic paralysis. In this issue of the JCI, Jarecki and colleagues present evidence suggesting that many such mutations alter the gating of sodium channels to produce resurgent sodium current, an unusual form of gating in which sodium channels reopen following an action potential, thus promoting the firing of another action potential (see the related article beginning on page 369). The results of this study suggest a widespread pathophysiological role for this mechanism, previously described to occur normally in only a few types of neurons.

Original languageEnglish (US)
Pages (from-to)80-83
Number of pages4
JournalJournal of Clinical Investigation
Volume120
Issue number1
DOIs
StatePublished - Jan 4 2010

Fingerprint

Channelopathies
Sodium Channels
Muscles
Action Potentials
Myotonia
Neurons
Mutation
Inborn Genetic Diseases
Paralysis
Cardiac Arrhythmias
Epilepsy
Myocardium
Skeletal Muscle
Sodium

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Sodium channels gone wild : Resurgent current from neuronal and muscle channelopathies. / Cannon, Stephen C.; Bean, Bruce P.

In: Journal of Clinical Investigation, Vol. 120, No. 1, 04.01.2010, p. 80-83.

Research output: Contribution to journalArticle

Cannon, Stephen C. ; Bean, Bruce P. / Sodium channels gone wild : Resurgent current from neuronal and muscle channelopathies. In: Journal of Clinical Investigation. 2010 ; Vol. 120, No. 1. pp. 80-83.
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