Solitary cylindroma (dermal analog tumor) of the breast: A previously undescribed neoplasm at this site

S. Tunc Gokaslan, Brian Carlile, M. Dudak, Jorge Albores-Saavedra

Research output: Contribution to journalArticle

21 Citations (Scopus)

Abstract

The authors report a previously undescribed small, well-demarcated breast tumor similar to a dermal cylindroma in a 63-year-old woman. The tumor was an incidental finding in a lumpectomy specimen for infiltrating lobular carcinoma. The cylindroma was surrounded by normal-appearing breast parenchyma and had the typical "jigsaw" pattern of epithelial basaloid islands. The islands showed focal squamous and myoepithelial differentiation. A notable number of reactive dendritic Langerhans cells permeated the epithelial cell islands, a feature considered to be characteristic of dermal cylindroma. There was also ductal differentiation. Thick bands of hyaline periodic acid-Schiff (PAS) stain and collagen IV-positive basement membrane material bordered the cell islands, and PAS-collagen IV-positive hyaline globules were seen within the cell islands. There was no nuclear pleomorphism or mitotic figures. The cylindroma did not express gross cystic disease fluid protein 15, carcinoembryonic antigen, estrogen and progesterone receptors, or cytokeratin 20 (CK20). There was diffuse and strong immunoreactivity to CK AE1/AE3, and focal reactivity for CK7 and smooth muscle actin. Cylindroma of the breast should be distinguished from adenoid cystic carcinoma and basal cell carcinoma. Although clearly epithelial, the exact histogenesis and cell phenotype of this unusual dermal type cylindroma of the breast are unknown.

Original languageEnglish (US)
Pages (from-to)823-826
Number of pages4
JournalAmerican Journal of Surgical Pathology
Volume25
Issue number6
DOIs
StatePublished - 2001

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Neoplasms by Site
Adenoid Cystic Carcinoma
Breast Neoplasms
Skin
Periodic Acid
Breast
Hyalin
Islands
Collagen
Keratin-20
Lobular Carcinoma
Antigen Receptors
Incidental Findings
Langerhans Cells
Segmental Mastectomy
Basal Cell Carcinoma
Carcinoembryonic Antigen
Progesterone Receptors
Basement Membrane
Estrogen Receptors

Keywords

  • Breast
  • Cylindroma
  • Dermal analog tumor

ASJC Scopus subject areas

  • Anatomy
  • Pathology and Forensic Medicine

Cite this

Solitary cylindroma (dermal analog tumor) of the breast : A previously undescribed neoplasm at this site. / Gokaslan, S. Tunc; Carlile, Brian; Dudak, M.; Albores-Saavedra, Jorge.

In: American Journal of Surgical Pathology, Vol. 25, No. 6, 2001, p. 823-826.

Research output: Contribution to journalArticle

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