@inproceedings{4feb4f1e78ba491eb27a53c086226e6b,
title = "Soluble adenylyl cyclase: Potential role in mineral metabolism",
abstract = "The conversion of a signal of inorganic ion concentration to a second messenger is of fundamental biologic significance. The soluble adenylyl cyclase (sAC) serves such a purpose by transducing divalent cation concentrations and bicarbonate concentrations into intracellular cyclic AMP levels. sAC is widely expressed and may represent a generic bicarbonate sensor providing the afferent pathway to bicarbonate-regulated biologic processes. The best described action of sAC to date is in the mediation of bicarbonate-induced changes in sperm motility. Since a number of processes in mineral metabolism - such as bone formation, bone resorption, intestinal calcium absorption, and renal calcium transport in the distal convoluted tubule - are regulated by bicarbonate, sAC may play a role at multiple levels in mineral metabolism.",
keywords = "Calcium, Second messengers",
author = "Weidong Geng and Moe, {Orson W.}",
year = "2007",
month = may,
day = "11",
language = "English (US)",
isbn = "0735404062",
series = "AIP Conference Proceedings",
pages = "95--102",
booktitle = "RENAL STONE DISEASE",
note = "1st Annual International Urolithiasis Research Symposium ; Conference date: 02-11-2006 Through 03-11-2006",
}