Soluble adenylyl cyclase

Potential role in mineral metabolism

Weidong Geng, Orson W. Moe

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

The conversion of a signal of inorganic ion concentration to a second messenger is of fundamental biologic significance. The soluble adenylyl cyclase (sAC) serves such a purpose by transducing divalent cation concentrations and bicarbonate concentrations into intracellular cyclic AMP levels. sAC is widely expressed and may represent a generic bicarbonate sensor providing the afferent pathway to bicarbonate-regulated biologic processes. The best described action of sAC to date is in the mediation of bicarbonate-induced changes in sperm motility. Since a number of processes in mineral metabolism - such as bone formation, bone resorption, intestinal calcium absorption, and renal calcium transport in the distal convoluted tubule - are regulated by bicarbonate, sAC may play a role at multiple levels in mineral metabolism.

Original languageEnglish (US)
Title of host publicationAIP Conference Proceedings
Pages95-102
Number of pages8
Volume900
StatePublished - 2007
Event1st Annual International Urolithiasis Research Symposium - Indianapolis, IN, United States
Duration: Nov 2 2006Nov 3 2006

Other

Other1st Annual International Urolithiasis Research Symposium
CountryUnited States
CityIndianapolis, IN
Period11/2/0611/3/06

Fingerprint

mineral metabolism
carbonates
calcium
cyclic AMP
osteogenesis
mediation
locomotion
ion concentration
bones
cations
sensors

Keywords

  • Calcium
  • Second messengers

ASJC Scopus subject areas

  • Physics and Astronomy(all)

Cite this

Geng, W., & Moe, O. W. (2007). Soluble adenylyl cyclase: Potential role in mineral metabolism. In AIP Conference Proceedings (Vol. 900, pp. 95-102)

Soluble adenylyl cyclase : Potential role in mineral metabolism. / Geng, Weidong; Moe, Orson W.

AIP Conference Proceedings. Vol. 900 2007. p. 95-102.

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Geng, W & Moe, OW 2007, Soluble adenylyl cyclase: Potential role in mineral metabolism. in AIP Conference Proceedings. vol. 900, pp. 95-102, 1st Annual International Urolithiasis Research Symposium, Indianapolis, IN, United States, 11/2/06.
Geng W, Moe OW. Soluble adenylyl cyclase: Potential role in mineral metabolism. In AIP Conference Proceedings. Vol. 900. 2007. p. 95-102
Geng, Weidong ; Moe, Orson W. / Soluble adenylyl cyclase : Potential role in mineral metabolism. AIP Conference Proceedings. Vol. 900 2007. pp. 95-102
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