Somatostatin analogs inhibit somatostatin release

E. Ipp, J. Rivier, R. E. Dobbs, M. Brown, W. Vale, Roger H Unger

Research output: Contribution to journalArticle

28 Scopus citations


To determine if, like insulin, somatostatin inhibits its own secretion from the pancreas, nonimmunoreactive analogs of somatostatin were perfused in an isolated dog pancreaticoduodenal preparation using a nonrecirculating system. [D-Trp8-D-Cys14]somatostatin, at a concentration of 200 ng/ml, blocked the response of somatostatin-like immunoreactivity (SLI) to cholecystokinin and arginine. When perfusion of the analog was discontinued, SLI release increased. At a concentration of 0.1 ng/ml, des Asn5-[D-Trp8]somatostatin lowered SLI levels significantly without significantly reducing glucagon levels. At a concentration of 1 ng/ml, des Asn5-[D-Trp8]somatostatin significantly inhibited SLI as well as insulin and glucagon release. Perfusion of glucagon at a concentration of 10 ng/ml failed to overcome the blockade of SLI and insulin release caused by 50 ng/ml des Asn5-[D-Trp8]somatostatin. The results are compatible with a direct inhibitory effect of somatostatin analogs upon SLI release and raise the possibility of a self-inhibiting action of the native hormone.

Original languageEnglish (US)
Pages (from-to)1270-1273
Number of pages4
Issue number5
StatePublished - May 1979

ASJC Scopus subject areas

  • Endocrinology

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    Ipp, E., Rivier, J., Dobbs, R. E., Brown, M., Vale, W., & Unger, R. H. (1979). Somatostatin analogs inhibit somatostatin release. Endocrinology, 104(5), 1270-1273.