@article{8283562364b74177a5c03e68db8330ad,
title = "Sonic hedgehog-regulated oligodendrocyte lineage genes encoding bHLH proteins in the mammalian central nervous system",
abstract = "During development, basic helix-loop-helix (bHLH) proteins regulate formation of neurons from multipotent progenitor cells. However, bHLH factors linked to gliogenesis have not been described. We have isolated a pair of oligodendrocyte lineage genes (Olg-1 and Olg-2) that encode bHLH proteins and are tightly associated with development of oligodendrocytes in the vertebrate central nervous system (CNS). Ectopic expression of Olg-1 in rat cortical progenitor cell cultures promotes formation of oligodendrocyte precursors. In developing mouse embryos, Olg gene expression overlaps but precedes the earliest known markers of the oligodendrocyte lineage. Olg genes are expressed at the telencephalon-diencephalon border and adjacent to the floor plate, a source of the secreted signaling molecule Sonic hedgehog (Shh). Gain- and loss-of-function analyses in transgenic mice demonstrate that Shh is both necessary and sufficient for Olg gene expression in vivo.",
author = "Lu, {Q. Richard} and Yuk, {Dong In} and Alberta, {John A.} and Zhimin Zhu and Inka Pawlitzky and Joanne Chan and McMahon, {Andrew P.} and Stiles, {Charles D.} and Rowitch, {David H.}",
note = "Funding Information: The authors wish to thank Drs. David Louis, Qiufu Ma, Tom Roberts, Matt Porteus, Mike Greenberg, Rosalind Segal, and Ben Barres for valuable comments and advice. We are grateful to Drs. Yann Echelard, Scott Pomeroy, Yi Sun, Anita Bhattacharyya, John Park, Amy Kavka, Jenny Zhang, Akio Yamakawa, and Sovann Som for technical assistance and/or suggestions. These studies were funded by grants from the National Institute of Child Health (HD24296 to C. D. S. and HD01182 to D. H. R.). Q. R. L. is a recipient of a National Research Service Award postdoctoral fellowship from the National Institutes of Health. D. H. R. is a Claudia Adams Barr Investigator and has also been supported by a Basil O'Conor Starter Scholar Award from the March of Dimes Foundation and a grant from the Brain Tumor Society. During the course of this work, we have learned that identical genes have been isolated and characterized independently by Q. Zhou and D. J. Anderson (California Institute of Technology), and they have observed a similar pattern of expression during early nervous system development (D. Anderson, personal communication). ",
year = "2000",
doi = "10.1016/S0896-6273(00)80897-1",
language = "English (US)",
volume = "25",
pages = "317--329",
journal = "Neuron",
issn = "0896-6273",
publisher = "Cell Press",
number = "2",
}