Sonoelastographic imaging of interference patterns for estimation of shear velocity distribution in biomaterials

The authors have recently demonstrated the shear wave interference patterns created by two coherent vibration sources imaged with the vibration sonoelastography technique. If the two sources vibrate at slightly different frequencies ω and ω+Δω, respectively, the interference patterns move at an apparent velocity of (Δω/2ω) *υ_shear, where υ_shear is the shear wave speed. We name the moving interference patterns "crawling waves." In this paper, we extend the techniques to inspect biomaterials with nonuniform stiffness distributions. A relationship between the local crawling wave speed and the local shear wave velocity is derived. In addition, a modified technique is proposed whereby only one shear wave source propagates shear waves into the medium at the frequency ω. The ultrasound probe is externally vibrated at the frequency ω-Δω. The resulting field estimated by the ultrasound (US) scanner is proven to be an exact representation of the propagating shear wave field. The authors name the apparent wave motion "holography waves." Real-time video sequences of both types of waves are acquired on various inhomogeneous elastic media. The distribution of the crawling/holographic wave speeds are estimated. The estimated wave speeds correlate with the stiffness distributions.