Sorting out signals in fly endosomes

Research output: Contribution to journalReview article

22 Scopus citations

Abstract

Ligands and receptors that mediate cell-cell interactions during development are removed from the cell surface by endocytosis. Subsequently, many of these internalized proteins are detected in multivesicular bodies (MVBs). Recent work in different organisms has elucidated some aspects of MVB biogenesis and trafficking. This review discusses some intriguing links between these findings, the sorting of proteins in endocytic trafficking, and the regulation of signaling pathways in Drosophila.

Original languageEnglish (US)
Pages (from-to)87-91
Number of pages5
JournalTraffic
Volume3
Issue number2
DOIs
StatePublished - Jun 5 2002

Keywords

  • Delivery
  • EGF receptor
  • Exosomes
  • Lysosomal MVBs
  • Mono-ubiquitination
  • Notch
  • Wingless

ASJC Scopus subject areas

  • Structural Biology
  • Biochemistry
  • Molecular Biology
  • Genetics
  • Cell Biology

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