Sorting out Toll Signals

Katherine A. Fitzgerald, Zhijian J. Chen

Research output: Contribution to journalArticle

77 Citations (Scopus)

Abstract

Upon recognition of microbial products, Toll-like receptors (TLRs) recruit distinct combinations of adaptors to induce TLR-specific gene expression. In this issue, Kagan and Medzhitov (2006) demonstrate that the adaptor TIRAP/Mal localizes to the plasma membrane by binding to phosphatidylinositol 4,5-bisphosphate (PIP2). This binding recruits a key adaptor MyD88 to TLR4, suggesting that there is crosstalk between the TLR signaling pathway and phospholipid metabolism.

Original languageEnglish (US)
Pages (from-to)834-836
Number of pages3
JournalCell
Volume125
Issue number5
DOIs
StatePublished - Jun 2 2006

Fingerprint

Toll-Like Receptors
Sorting
Cell membranes
Crosstalk
Phosphatidylinositols
Metabolism
Gene expression
Phospholipids
Cell Membrane
Gene Expression

ASJC Scopus subject areas

  • Cell Biology
  • Molecular Biology

Cite this

Sorting out Toll Signals. / Fitzgerald, Katherine A.; Chen, Zhijian J.

In: Cell, Vol. 125, No. 5, 02.06.2006, p. 834-836.

Research output: Contribution to journalArticle

Fitzgerald, KA & Chen, ZJ 2006, 'Sorting out Toll Signals', Cell, vol. 125, no. 5, pp. 834-836. https://doi.org/10.1016/j.cell.2006.05.014
Fitzgerald, Katherine A. ; Chen, Zhijian J. / Sorting out Toll Signals. In: Cell. 2006 ; Vol. 125, No. 5. pp. 834-836.
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