Southwestern Internal Medicine Conference: Retinoids - 'Differentiation agents' for cancer treatment and prevention

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21 Scopus citations

Abstract

The ability of vitamin A and its derivatives to induce differentiation in certain target tissues has been appreciated for nearly a century. Recently, oral all-trans retinoic acid (ATRA), a vitamin A metabolite, has been shown to induce terminal differentiation of leukemic cells in patients with acute promyelocytic leukemia (APL). Complete remissions are obtained and normal hematopoiesis is established in an outpatient setting with minimal side effects in the majority of cases. Although remissions are not durable, disseminated intravascular coagulation, a frequent complication of remission induction in APL, is avoided by oral ATRA prior to definitive chemotherapy. The molecular basis for the efficacy of ATRA in APL appears to be the involvement of the retinoic acid receptor α locus in the t(15;17) translocation breakpoint characteristic of APL.

Original languageEnglish (US)
Pages (from-to)202-213
Number of pages12
JournalAmerican Journal of the Medical Sciences
Volume304
Issue number3
DOIs
StatePublished - 1992

Keywords

  • Acute promyelocytic leukemia
  • Chemoprevention
  • Differentiation
  • Retinoids

ASJC Scopus subject areas

  • Medicine(all)

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