SOX10 Immunoexpression in Basaloid Squamous Cell Carcinomas: A Diagnostic Pitfall for Ruling out Salivary Differentiation

Lisa M. Rooper, Austin M. McCuiston, William H. Westra, Justin A. Bishop

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

SOX10 immunoexpression is increasingly recognized in salivary gland tumors, including but not limited to those with myoepithelial, serous acinar, and intercalated duct differentiation. However, SOX10 expression has not been extensively evaluated in other epithelial tumors that can mimic salivary origin. Basaloid squamous cell carcinoma (SCC) is a unique variant of SCC that shows morphologic overlap with several salivary tumors, including adenoid cystic carcinoma, basal cell adenocarcinoma, and myoepithelial carcinoma. We performed SOX10 immunohistochemistry on 22 basaloid SCCs and 280 non-basaloid SCCs. If tissue was available, we also performed immunohistochemistry for S100 and p16, and in-situ hybridization for high-risk HPV RNA. SOX10 was positive in 13/22 basaloid SCCs (59%), including 5/6 (83%) that were HPV-positive and 6/12 (50%) that were HPV-negative. Only 2/12 basaloid SCC (17%) demonstrated focal S100 expression. All non-basaloid SCCs were SOX10 negative. Frequent positivity for SOX10 in basaloid SCC presents a significant diagnostic pitfall for distinguishing these tumors from various basaloid salivary carcinomas. The preponderance of SOX10 expression in the basaloid variant of HPV-positive SCC also presents a diagnostic challenge in separating it from HPV-related multiphenotypic sinonasal carcinoma. SOX10 may be more broadly considered a marker of basal differentiation and should not be assumed to be specific for salivary origin in epithelial head and neck tumors.

Original languageEnglish (US)
Pages (from-to)543-547
Number of pages5
JournalHead and Neck Pathology
Volume13
Issue number4
DOIs
StatePublished - Dec 1 2019

Fingerprint

Squamous Cell Carcinoma
Carcinoma
Neoplasms
Immunohistochemistry
Human papillomavirus 6
Adenoid Cystic Carcinoma
Glandular and Epithelial Neoplasms
Differentiation Antigens
In Situ Hybridization
Adenocarcinoma
Neck
Head
RNA

Keywords

  • Basaloid squamous cell carcinoma
  • Human papillomavirus
  • Immunohistochemistry
  • SOX10
  • Squamous cell carcinoma

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Otorhinolaryngology
  • Oncology

Cite this

SOX10 Immunoexpression in Basaloid Squamous Cell Carcinomas : A Diagnostic Pitfall for Ruling out Salivary Differentiation. / Rooper, Lisa M.; McCuiston, Austin M.; Westra, William H.; Bishop, Justin A.

In: Head and Neck Pathology, Vol. 13, No. 4, 01.12.2019, p. 543-547.

Research output: Contribution to journalArticle

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