SPARCL1 suppresses metastasis in prostate cancer

Yuzhu Xiang, Qingchao Qiu, Ming Jiang, Renjie Jin, Brian D. Lehmann, Douglas W. Strand, Bojana Jovanovic, David J. DeGraff, Yi Zheng, Dina A. Yousif, Christine Q. Simmons, Thomas C. Case, Jia Yi, Justin M. Cates, John Virostko, Xiusheng He, Xunbo Jin, Simon W. Hayward, Robert J. Matusik, AlfredL GeorgeYajun Yi

Research output: Contribution to journalArticlepeer-review

21 Scopus citations

Abstract

Purpose: Metastasis, the main cause of death from cancer, remains poorly understood at the molecular level. Experimental design: Based on a pattern of reduced expression in human prostate cancer tissues and tumor cell lines, a candidate suppressor gene (SPARCL1) was identified. We used invitro approaches to determine whether overexpression of SPARCL1 affects cell growth, migration, and invasiveness. We then employed xenograft mouse models to analyze the impact of SPARCL1 on prostate cancer cell growth and metastasis invivo. Results: SPARCL1 expression did not inhibit tumor cell proliferation invitro. By contrast, SPARCL1 did suppress tumor cell migration and invasiveness invitro and tumor metastatic growth invivo, conferring improved survival in xenograft mouse models. Conclusions: We present the first invivo data suggesting that SPARCL1 suppresses metastasis of prostate cancer.

Original languageEnglish (US)
Pages (from-to)1019-1030
Number of pages12
JournalMolecular oncology
Volume7
Issue number6
DOIs
StatePublished - Dec 2013

Keywords

  • Gene expression signature
  • Meta-analysis
  • Metastasis
  • Prostate cancer
  • SPARCL1 function invivo

ASJC Scopus subject areas

  • Molecular Medicine
  • Genetics
  • Oncology
  • Cancer Research

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