Spatial compartmentalization of lipid droplet biogenesis

Mike Henne, Joel M Goodman, Hanaa Hariri

Research output: Contribution to journalReview article

Abstract

Lipid droplets (LDs) are ubiquitous organelles that store metabolic energy in the form of neutral lipids (typically triacylglycerols and steryl esters). Beyond being inert energy storage compartments, LDs are dynamic organelles that participate in numerous essential metabolic functions. Cells generate LDs de novo from distinct sub-regions at the endoplasmic reticulum (ER), but what determines sites of LD formation remains a key unanswered question. Here, we review the factors that determine LD formation at the ER, and discuss how they work together to spatially and temporally coordinate LD biogenesis. These factors include lipid synthesis enzymes, assembly proteins, and membrane structural requirements. LDs also make contact with other organelles, and these inter-organelle contacts contribute to defining sites of LD production. Finally, we highlight emerging non-canonical roles for LDs in maintaining cellular homeostasis during stress.

Original languageEnglish (US)
JournalBiochimica et Biophysica Acta - Molecular and Cell Biology of Lipids
DOIs
StateAccepted/In press - Jan 1 2019

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Organelles
Endoplasmic Reticulum
Lipids
Lipid Droplets
Membrane Proteins
Esters
Triglycerides
Homeostasis
Enzymes

Keywords

  • Endoplasmic reticulum
  • Fatty acid
  • Lipid droplet
  • Lipotoxicity
  • Metabolon

ASJC Scopus subject areas

  • Molecular Biology
  • Cell Biology

Cite this

Spatial compartmentalization of lipid droplet biogenesis. / Henne, Mike; Goodman, Joel M; Hariri, Hanaa.

In: Biochimica et Biophysica Acta - Molecular and Cell Biology of Lipids, 01.01.2019.

Research output: Contribution to journalReview article

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