Spatiotemporal and frequency domain analysis of auditory paired stimuli processing in schizophrenia and bipolar disorder with psychosis

Jordan P. Hamm, Lauren E. Ethridge, John R. Shapiro, Michael C. Stevens, Nashaat N. Boutros, Ann T. Summerfelt, Matcheri S. Keshavan, John A. Sweeney, Godfrey Pearlson, Carol A. Tamminga, Gunvant Thaker, Brett A. Clementz

Research output: Contribution to journalArticle

34 Scopus citations

Abstract

Individuals with schizophrenia (SZ) or bipolar disorder with psychosis (BPP) may share neurophysiological abnormalities as measured in auditory paired-stimuli paradigms with electroencephalography (EEG). Such investigations have been limited, however, by quantifying only event-related potential peaks and/or broad frequency bands at limited scalp locations without considering possible mediating factors (e.g., baseline differences). Results from 64-sensor EEG collected in 180 age- and gender-matched participants reveal (i) accentuated prestimulus gamma oscillations and (ii) reduced P2 amplitudes and theta/alpha oscillations to S1 among participants with both SZ and BPP. Conversely, (iii) N1s in those with SZ to S1 were reduced compared to healthy volunteers and those with BPP, whereas (iv) beta range oscillations 200-300ms following S2 were accentuated in those with BPP but not those with SZ. Results reveal a pattern of both unique and shared neurophysiological phenotypes occurring within major psychotic diagnoses.

Original languageEnglish (US)
Pages (from-to)522-530
Number of pages9
JournalPsychophysiology
Volume49
Issue number4
DOIs
StatePublished - Apr 2012

Keywords

  • EEG/ERP
  • Psychopathological
  • Sensation/perception

ASJC Scopus subject areas

  • Neuroscience(all)
  • Neuropsychology and Physiological Psychology
  • Experimental and Cognitive Psychology
  • Neurology
  • Endocrine and Autonomic Systems
  • Developmental Neuroscience
  • Cognitive Neuroscience
  • Biological Psychiatry

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  • Cite this

    Hamm, J. P., Ethridge, L. E., Shapiro, J. R., Stevens, M. C., Boutros, N. N., Summerfelt, A. T., Keshavan, M. S., Sweeney, J. A., Pearlson, G., Tamminga, C. A., Thaker, G., & Clementz, B. A. (2012). Spatiotemporal and frequency domain analysis of auditory paired stimuli processing in schizophrenia and bipolar disorder with psychosis. Psychophysiology, 49(4), 522-530. https://doi.org/10.1111/j.1469-8986.2011.01327.x