Special Delivery: Granulin Brings CpG DNA to Toll-like Receptor 9

Eva Marie Y Moresco, Bruce Beutler

Research output: Contribution to journalShort survey

12 Scopus citations

Abstract

Foreign DNA activates the innate immune response through Toll-like receptor 9 (TLR9). In this issue of Immunity, Park et al. (2011) present evidence that granulin is a cofactor for TLR9 activation, delivering CpG-oligodeoxynucleotides to TLR9 in endolysosomes.

Original languageEnglish (US)
Pages (from-to)453-455
Number of pages3
JournalImmunity
Volume34
Issue number4
DOIs
StatePublished - Apr 22 2011

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology
  • Infectious Diseases

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