Specialized Intercellular Communications via Cytonemes and Nanotubes

Yukiko M. Yamashita, Mayu Inaba, Michael Buszczak

Research output: Contribution to journalReview article

8 Citations (Scopus)

Abstract

In recent years, thin membrane protrusions such as cytonemes and tunneling nanotubes have emerged as a novel mechanism of intercellular communication. Protrusion-based cellular interactions allow for specific communication between participating cells and have a distinct spectrum of advantages compared to secretion- and diffusion-based intercellular communication. Identification of protrusion-based signaling in diverse systems suggests that this mechanism is a ubiquitous and prevailing means of communication employed by many cell types. Moreover, accumulating evidence indicates that protrusion-based intercellular communication is often involved in pathogenesis, including cancers and ections. Here we review our current understanding of protrusion-based intercellular communication.

Original languageEnglish (US)
Pages (from-to)59-84
Number of pages26
JournalAnnual Review of Cell and Developmental Biology
Volume34
DOIs
StatePublished - Oct 6 2018

Fingerprint

Nanotubes
Cell Surface Extensions
Membranes
Neoplasms

Keywords

  • Adult stem cells
  • Cytoneme
  • Nanotube
  • Signaling
  • Stem cell niche

ASJC Scopus subject areas

  • Developmental Biology
  • Cell Biology

Cite this

Specialized Intercellular Communications via Cytonemes and Nanotubes. / Yamashita, Yukiko M.; Inaba, Mayu; Buszczak, Michael.

In: Annual Review of Cell and Developmental Biology, Vol. 34, 06.10.2018, p. 59-84.

Research output: Contribution to journalReview article

@article{9deae87668874c9fa98d2eb2fe2accaa,
title = "Specialized Intercellular Communications via Cytonemes and Nanotubes",
abstract = "In recent years, thin membrane protrusions such as cytonemes and tunneling nanotubes have emerged as a novel mechanism of intercellular communication. Protrusion-based cellular interactions allow for specific communication between participating cells and have a distinct spectrum of advantages compared to secretion- and diffusion-based intercellular communication. Identification of protrusion-based signaling in diverse systems suggests that this mechanism is a ubiquitous and prevailing means of communication employed by many cell types. Moreover, accumulating evidence indicates that protrusion-based intercellular communication is often involved in pathogenesis, including cancers and ections. Here we review our current understanding of protrusion-based intercellular communication.",
keywords = "Adult stem cells, Cytoneme, Nanotube, Signaling, Stem cell niche",
author = "Yamashita, {Yukiko M.} and Mayu Inaba and Michael Buszczak",
year = "2018",
month = "10",
day = "6",
doi = "10.1146/annurev-cellbio-100617-062932",
language = "English (US)",
volume = "34",
pages = "59--84",
journal = "Annual Review of Cell and Developmental Biology",
issn = "1081-0706",
publisher = "Annual Reviews Inc.",

}

TY - JOUR

T1 - Specialized Intercellular Communications via Cytonemes and Nanotubes

AU - Yamashita, Yukiko M.

AU - Inaba, Mayu

AU - Buszczak, Michael

PY - 2018/10/6

Y1 - 2018/10/6

N2 - In recent years, thin membrane protrusions such as cytonemes and tunneling nanotubes have emerged as a novel mechanism of intercellular communication. Protrusion-based cellular interactions allow for specific communication between participating cells and have a distinct spectrum of advantages compared to secretion- and diffusion-based intercellular communication. Identification of protrusion-based signaling in diverse systems suggests that this mechanism is a ubiquitous and prevailing means of communication employed by many cell types. Moreover, accumulating evidence indicates that protrusion-based intercellular communication is often involved in pathogenesis, including cancers and ections. Here we review our current understanding of protrusion-based intercellular communication.

AB - In recent years, thin membrane protrusions such as cytonemes and tunneling nanotubes have emerged as a novel mechanism of intercellular communication. Protrusion-based cellular interactions allow for specific communication between participating cells and have a distinct spectrum of advantages compared to secretion- and diffusion-based intercellular communication. Identification of protrusion-based signaling in diverse systems suggests that this mechanism is a ubiquitous and prevailing means of communication employed by many cell types. Moreover, accumulating evidence indicates that protrusion-based intercellular communication is often involved in pathogenesis, including cancers and ections. Here we review our current understanding of protrusion-based intercellular communication.

KW - Adult stem cells

KW - Cytoneme

KW - Nanotube

KW - Signaling

KW - Stem cell niche

UR - http://www.scopus.com/inward/record.url?scp=85054620741&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85054620741&partnerID=8YFLogxK

U2 - 10.1146/annurev-cellbio-100617-062932

DO - 10.1146/annurev-cellbio-100617-062932

M3 - Review article

C2 - 30074816

AN - SCOPUS:85054620741

VL - 34

SP - 59

EP - 84

JO - Annual Review of Cell and Developmental Biology

JF - Annual Review of Cell and Developmental Biology

SN - 1081-0706

ER -