Species-specific class I gene expansions formed the telomeric 1 Mb of the mouse major histocompatibility complex

Toyoyuki Takada, Attila Kumánovics, Claire Amadou, Masayasu Yoshino, Elsy P. Jones, Maria Athanasiou, Glen A. Evans, Kirsten Fischer Lindahl

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Abstract

We have determined the complete sequence of 951,695 bp from the class I region of H2, the mouse major histocompatibility complex (Mhc) from strain 129/Sv (haplotype bc). The sequence contains 26 genes. The sequence spans from the last 50 kb of the H2-T region, including 2 class I genes and 3 class I pesudogenes, and includes the H2-M region up to Gabbr1. A 500-kb stretch of the H2-M region contains 9 class I genes and 4 pseudogenes, which fall into two subfamilies, M1 and M10, distinct from other mouse class I genes. This M1/M10 class I gene-cluster is separated from the centromeric H2-T and the telomeric H2-M4, -5 and -6 class I genes by "nonclass I genes". Comparison with the corresponding 853-kb region of the human Mhc, which includes the HLA-A region, shows a mosaic of conserved regions of orthologous nonclass I genes separated by regions of species-specific expansion of paralogous Mhc class I genes. The analysis of this mosaic structure illuminates the dynamic evolution of the Mhc class I region among mammals and provides evidence for the framework hypothesis.

Original languageEnglish (US)
Pages (from-to)589-600
Number of pages12
JournalGenome Research
Volume13
Issue number4
DOIs
StatePublished - Apr 1 2003

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ASJC Scopus subject areas

  • Genetics
  • Genetics(clinical)

Cite this

Takada, T., Kumánovics, A., Amadou, C., Yoshino, M., Jones, E. P., Athanasiou, M., Evans, G. A., & Lindahl, K. F. (2003). Species-specific class I gene expansions formed the telomeric 1 Mb of the mouse major histocompatibility complex. Genome Research, 13(4), 589-600. https://doi.org/10.1101/gr.975303