Specific binding of T lymphocytes to macrophages. V. The role of Ia antigens on Mφ in the binding

C. R. Lyons, T. F. Tucker, J. W. Uhr

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11 Scopus citations

Abstract

The effect of anti-Ia alloantiserum on the capacity of selected peritoneal exudate lymphocytes (selected PEL) to bind to antigen-pulsed F1 (responder x nonresponder) macrophages was investigated. With the use of selected PEL for antigens under Ir gene control, it was shown that anti-Ia serum to the responder haplotype blocked adherence of selected PEL to antigen-pulsed macrophages whereas anti-Ia serum to the nonresponder haplotype did not. The target cell of the anti-Ia alloantiserum appeared to be the macrophage because anti-13 Ia in contrast to anti-2 Ia did not inhibit binding of F1 (2 x 13) DNP-GL (GL = copolymer of L-glutamic acid and L-tyrosine) selected PEL to DNP-GL pulsed strain-2 Mφ (responder strain). Taken together with previous experiments that indicate that an antibody to the native protein antigen employed is unable to block specific binding, the present results suggest that T cells may recognize fragments of exogenous antigen in association with Ia molecules.

Original languageEnglish (US)
Pages (from-to)1598-1600
Number of pages3
JournalJournal of Immunology
Volume122
Issue number4
StatePublished - Dec 1 1979

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

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