Specific degradation of keratin in Xenopus laevis egg extracts undergoing apoptosis

S. Zhu, Z. Lu, Y. Sun, Z. Zhai

Research output: Contribution to journalArticle

2 Scopus citations

Abstract

Cytochrome c activates apoptosis specific protease XCPP32 when being added to Xenopus laevis egg extracts, and induces apoptosis in this cell-free system. During apoptosis, cyto-skeleton proteins in egg extracts are degraded. Western blot assay indicates that 42-ku acidic keratin in egg extracts has been degraded by XCPP32. The degradation of 42-ku keratin may be crucial in apoptosis.

Original languageEnglish (US)
Pages (from-to)1977-1981
Number of pages5
JournalChinese Science Bulletin
Volume45
Issue number21
DOIs
Publication statusPublished - Jan 1 2000

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Keywords

  • Apoptosis
  • Cytochrome c
  • Keratin
  • XCPP32
  • Xenopus laevis egg extracts

ASJC Scopus subject areas

  • General

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