Specific inhibition of T-cell-mediated cytolosis by alloantiserum against HLA-D-related (DR) antigens

C. F. Feighery, P. Stastny

Research output: Contribution to journalArticlepeer-review

14 Scopus citations

Abstract

Lymphocytes sensitized against HLA-A and B region-compatible, HLA-D region-incompatible stimulators were cytotoxic for target cells having the correct HLA-D antigens. This form of cytotoxicity was inhibited by platelet-absorbed pregnancy sera containing antibodies to the HLA-DR antigens of the target cells but not by sera with antibodies against other DR antigens. This form of CML was also inhibited by unlabeled monocytes and B cells of the relevant HLA-D specificity but not by T lymphocytes from the same donors.

Original languageEnglish (US)
Pages (from-to)708-711
Number of pages4
JournalTransplantation proceedings
Volume11
Issue number1
StatePublished - Jan 1 1979

ASJC Scopus subject areas

  • Surgery
  • Transplantation

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