Specific killing of a human breast carcinoma cell line by a monoclonal antibody coupled to the A-chain of ricin

Keith A. Krolick, Dorothy Yuan, Ellen S. Vitetta

Research output: Contribution to journalArticlepeer-review

29 Scopus citations

Abstract

We coupled monoclonal IgMk antibodies directed against human breast carcinoma cells to the A-chain of the plant toxin ricin. These molecular hybrids maintain both their antibody-binding activity and the toxic activity of the A-chain. Thus, they specifically bind to and kill the breast carcinoma cells in vitro.

Original languageEnglish (US)
Pages (from-to)39-41
Number of pages3
JournalCancer Immunology Immunotherapy
Volume12
Issue number1
DOIs
StatePublished - Dec 1 1981

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology
  • Oncology
  • Cancer Research

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