Specific [³H]-spiroperidol binding sites in human prefrontal cortex: Potential site multiplicity and overall serotonin-like selectivity

[³H]-Spiroperidol specifically binds at sites in human prefrontal cortex. The binding of this ligand is apparently anomalous at 37°C, with a substantial loss of specific binding occuring between 5 and 40 min incubation. However, at 21°C, this loss of binding is not observed even at 60 min. At 21°C, [³H]-spiroperidol binding in human prefrontal cortex is apparently occurring at multiple sites or multiple affinity states of single classes of sites, or at a combination of both. The overall selectivity is predominantly serotonergic, rather than dopaminergic.