Specific [3H]-spiroperidol binding sites in human prefrontal cortex: Potential site multiplicity and overall serotonin-like selectivity

Anne C. Andorn, Emina H. Huang, Anne E. Warren

Research output: Contribution to journalArticlepeer-review

13 Scopus citations

Abstract

[3H]-Spiroperidol specifically binds at sites in human prefrontal cortex. The binding of this ligand is apparently anomalous at 37°C, with a substantial loss of specific binding occuring between 5 and 40 min incubation. However, at 21°C, this loss of binding is not observed even at 60 min. At 21°C, [3H]-spiroperidol binding in human prefrontal cortex is apparently occurring at multiple sites or multiple affinity states of single classes of sites, or at a combination of both. The overall selectivity is predominantly serotonergic, rather than dopaminergic.

Original languageEnglish (US)
Pages (from-to)2461-2466
Number of pages6
JournalLife Sciences
Volume34
Issue number25
DOIs
StatePublished - Jun 18 1984
Externally publishedYes

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Pharmacology, Toxicology and Pharmaceutics(all)

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