Specificity in reactive oxidant signaling: Think globally, act locally

Research output: Contribution to journalArticle

166 Scopus citations

Abstract

Although reactive oxidants have long been stigmatized as unwanted metabolic byproducts, the expression of oxidases specifically functioning to produce these same molecules in a regulated fashion is surprisingly pervasive throughout metazoan and plant evolution. Although the involvement of oxidants in many signaling pathways is well documented, the cellular strategies for conferring pathway specificity to such reactive molecules have remained more recondite. Recent studies now suggest that cells may spatially restrict oxidant production to allow microdomain-specific signaling.

Original languageEnglish (US)
Pages (from-to)615-623
Number of pages9
JournalJournal of Experimental Medicine
Volume203
Issue number9
DOIs
StatePublished - Sep 4 2006

ASJC Scopus subject areas

  • Immunology

Fingerprint Dive into the research topics of 'Specificity in reactive oxidant signaling: Think globally, act locally'. Together they form a unique fingerprint.

  • Cite this