TY - JOUR
T1 - Specificity in reactive oxidant signaling
T2 - Think globally, act locally
AU - Terada, Lance S.
PY - 2006/9/4
Y1 - 2006/9/4
N2 - Although reactive oxidants have long been stigmatized as unwanted metabolic byproducts, the expression of oxidases specifically functioning to produce these same molecules in a regulated fashion is surprisingly pervasive throughout metazoan and plant evolution. Although the involvement of oxidants in many signaling pathways is well documented, the cellular strategies for conferring pathway specificity to such reactive molecules have remained more recondite. Recent studies now suggest that cells may spatially restrict oxidant production to allow microdomain-specific signaling.
AB - Although reactive oxidants have long been stigmatized as unwanted metabolic byproducts, the expression of oxidases specifically functioning to produce these same molecules in a regulated fashion is surprisingly pervasive throughout metazoan and plant evolution. Although the involvement of oxidants in many signaling pathways is well documented, the cellular strategies for conferring pathway specificity to such reactive molecules have remained more recondite. Recent studies now suggest that cells may spatially restrict oxidant production to allow microdomain-specific signaling.
UR - http://www.scopus.com/inward/record.url?scp=33748466565&partnerID=8YFLogxK
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U2 - 10.1083/jcb.200605036
DO - 10.1083/jcb.200605036
M3 - Article
C2 - 16923830
SN - 0022-1007
VL - 203
SP - 615
EP - 623
JO - Journal of Experimental Medicine
JF - Journal of Experimental Medicine
IS - 9
ER -