Specificity of androgen resistance in Mus caroli kidney

Carol M. Wilson, Debora F. Kimberlin, Jim Griffin III, Jean D. Wilson

Research output: Contribution to journalArticle

2 Scopus citations

Abstract

Androgen controls the expression of β-glucuronidase and several other proteins in the kidney of the standard laboratory mouse, Mus musculus. Other species within the genus Mus exhibit a variety of response patterns for kidney β-glucuronidase and other markers of androgen action. We have investigated the mechanism of androgen action in M. caroli, a Mus species that does not produce β-glucuronidase in response to testosterone. The failure of testosterone to induce β-glucuronidase in M. caroli females cannot be overcome by treatment with dihydrotestosterone, with pharmacological doses of testosterone propionate or dihydrotestosterone propionate, or with a variety of potent androgen analogues. All of these compounds induce kidney β-glucuronidase in M. musculus females and kidney ornithine decarboxylase, submandibular gland renin, and submandibular gland epidermal growth factor in both M. caroli and M. musculus females. Furthermore, kidney androgen receptor proteins from M. caroli and M. musculus animals have the same sedimentation characteristics on sucrose density gradients. These data indicate that androgen resistance in M. caroli is not due to deficient 5α-reductase or aberrant hormone metabolism producing suboptimal levels of functional androgen and is not caused by a defective androgen receptor. They suggest that the resistance of β-glucuronidase in M. caroli kidney to induction by androgen occurs at the level of the β-glucuronidase gene.

Original languageEnglish (US)
Pages (from-to)705-716
Number of pages12
JournalBiochemical Genetics
Volume26
Issue number11-12
DOIs
StatePublished - Jan 1 1988

Keywords

  • androgen
  • kidney
  • Mus caroli
  • Mus musculus
  • submandibular gland

ASJC Scopus subject areas

  • Biochemistry
  • Ecology, Evolution, Behavior and Systematics
  • Molecular Biology
  • Genetics

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