Specificity of cell mediated lympholysis for public and private H 2 determinants

K. F. Lindahl, A. B. Peck, F. H. Bach

Research output: Contribution to journalArticle

31 Citations (Scopus)

Abstract

The specificity of cell mediated lympholysis in the mouse was investigated by studying the cross reactivity of in vitro generated effector cells against targets carrying H 2 haplotypes which differs from that of the stimulator. Congenic resistant partners of the C57BL/10 strain carrying ten different, independently derived haplotypes were tested in more than 600 combinations. Strong cytotoxicity was observed when stimulator and target cells shared a private determinant, but considerable cross killing was also seen in combinations where stimulator and target cells shared only public determinants. Cross killing is specific and can be blocked only by unlabeled cells of the stimulator or target strain. Although cross killing does not correlate with the number of stimulating public determinants carried by the target, individual determinants 3, 13, 25, and 27 + 28 + 29 are associated with increased cross killing. Cross killing can occur both at the K and the D end of H 2 and is not explained by antigens determined by the I region. It is concluded that the serologically defined H 2K and H 2D molecules are the primary targets for cytotoxic T lymphocytes but that they may be perceived differently by T and B lymphocytes.

Original languageEnglish (US)
Pages (from-to)541-553
Number of pages13
JournalScandinavian Journal of Immunology
Volume4
Issue number5-6
StatePublished - 1975

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Haplotypes
Cytotoxic T-Lymphocytes
B-Lymphocytes
T-Lymphocytes
In Vitro Techniques
I-antigen

ASJC Scopus subject areas

  • Immunology

Cite this

Specificity of cell mediated lympholysis for public and private H 2 determinants. / Lindahl, K. F.; Peck, A. B.; Bach, F. H.

In: Scandinavian Journal of Immunology, Vol. 4, No. 5-6, 1975, p. 541-553.

Research output: Contribution to journalArticle

Lindahl, K. F. ; Peck, A. B. ; Bach, F. H. / Specificity of cell mediated lympholysis for public and private H 2 determinants. In: Scandinavian Journal of Immunology. 1975 ; Vol. 4, No. 5-6. pp. 541-553.
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