Spectral polarization imaging of human prostate cancer tissue using a near-infrared receptor-targeted contrast agent

Y. Pu; W. B. Wang; G. C. Tang; F. Zeng; S. Achilefu; J. H. Vitenson; I. Sawczuk; S. Peters; J. M. Lombardo; R. R. Alfano

doi:10.1177/153303460500400410

Spectral polarization imaging of human prostate cancer tissue using a near-infrared receptor-targeted contrast agent

Y. Pu, W. B. Wang, G. C. Tang, F. Zeng, S. Achilefu, J. H. Vitenson, I. Sawczuk, S. Peters, J. M. Lombardo, R. R. Alfano

Research output: Contribution to journal › Article › peer-review

69 Scopus citations

Abstract

The Cypate-Bombesin Peptide Analogue Conjugate (Cybesin) was used as a prostate tumor receptor-targeted contrast agent. The absorption and fluorescence spectra of Cybesin were measured and shown to exist in the NIR tissue "optical window". The spectral polarization imaging of Cybesin-stained prostate cancerous and normal tissues shows that prostate cancerous tissue takes-up more Cybesin than that of prostate normal tissue, making Cybesin a potential marker of prostate cancer.

Original language	English (US)
Pages (from-to)	429-436
Number of pages	8
Journal	Technology in Cancer Research and Treatment
Volume	4
Issue number	4
DOIs	https://doi.org/10.1177/153303460500400410
State	Published - Aug 2005
Externally published	Yes

Keywords

Absorption
And Fluorescence
Contrast agent
Near-infrared
Peptide analogue conjugate
Prostate cancer
Receptor-targeted
Spectral polarization imaging

ASJC Scopus subject areas

Oncology
Cancer Research

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10.1177/153303460500400410

Cite this

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title = "Spectral polarization imaging of human prostate cancer tissue using a near-infrared receptor-targeted contrast agent",

abstract = "The Cypate-Bombesin Peptide Analogue Conjugate (Cybesin) was used as a prostate tumor receptor-targeted contrast agent. The absorption and fluorescence spectra of Cybesin were measured and shown to exist in the NIR tissue {"}optical window{"}. The spectral polarization imaging of Cybesin-stained prostate cancerous and normal tissues shows that prostate cancerous tissue takes-up more Cybesin than that of prostate normal tissue, making Cybesin a potential marker of prostate cancer.",

keywords = "Absorption, And Fluorescence, Contrast agent, Near-infrared, Peptide analogue conjugate, Prostate cancer, Receptor-targeted, Spectral polarization imaging",

author = "Y. Pu and Wang, {W. B.} and Tang, {G. C.} and F. Zeng and S. Achilefu and Vitenson, {J. H.} and I. Sawczuk and S. Peters and Lombardo, {J. M.} and Alfano, {R. R.}",

year = "2005",

month = aug,

doi = "10.1177/153303460500400410",

language = "English (US)",

volume = "4",

pages = "429--436",

journal = "Technology in Cancer Research and Treatment",

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TY - JOUR

T1 - Spectral polarization imaging of human prostate cancer tissue using a near-infrared receptor-targeted contrast agent

AU - Pu, Y.

AU - Wang, W. B.

AU - Tang, G. C.

AU - Zeng, F.

AU - Achilefu, S.

AU - Vitenson, J. H.

AU - Sawczuk, I.

AU - Peters, S.

AU - Lombardo, J. M.

AU - Alfano, R. R.

PY - 2005/8

Y1 - 2005/8

N2 - The Cypate-Bombesin Peptide Analogue Conjugate (Cybesin) was used as a prostate tumor receptor-targeted contrast agent. The absorption and fluorescence spectra of Cybesin were measured and shown to exist in the NIR tissue "optical window". The spectral polarization imaging of Cybesin-stained prostate cancerous and normal tissues shows that prostate cancerous tissue takes-up more Cybesin than that of prostate normal tissue, making Cybesin a potential marker of prostate cancer.

AB - The Cypate-Bombesin Peptide Analogue Conjugate (Cybesin) was used as a prostate tumor receptor-targeted contrast agent. The absorption and fluorescence spectra of Cybesin were measured and shown to exist in the NIR tissue "optical window". The spectral polarization imaging of Cybesin-stained prostate cancerous and normal tissues shows that prostate cancerous tissue takes-up more Cybesin than that of prostate normal tissue, making Cybesin a potential marker of prostate cancer.

KW - Absorption

KW - And Fluorescence

KW - Contrast agent

KW - Near-infrared

KW - Peptide analogue conjugate

KW - Prostate cancer

KW - Receptor-targeted

KW - Spectral polarization imaging

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DO - 10.1177/153303460500400410

M3 - Article

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AN - SCOPUS:24144433475

SN - 1533-0346

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JO - Technology in Cancer Research and Treatment

JF - Technology in Cancer Research and Treatment

IS - 4

ER -

Spectral polarization imaging of human prostate cancer tissue using a near-infrared receptor-targeted contrast agent

Abstract

Keywords

ASJC Scopus subject areas

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