Spectral polarization imaging of human prostate cancer tissue using a near-infrared receptor-targeted contrast agent

Y. Pu, W. B. Wang, G. C. Tang, F. Zeng, S. Achilefu, J. H. Vitenson, I. Sawczuk, S. Peters, J. M. Lombardo, R. R. Alfano

Research output: Contribution to journalArticlepeer-review

67 Scopus citations

Abstract

The Cypate-Bombesin Peptide Analogue Conjugate (Cybesin) was used as a prostate tumor receptor-targeted contrast agent. The absorption and fluorescence spectra of Cybesin were measured and shown to exist in the NIR tissue "optical window". The spectral polarization imaging of Cybesin-stained prostate cancerous and normal tissues shows that prostate cancerous tissue takes-up more Cybesin than that of prostate normal tissue, making Cybesin a potential marker of prostate cancer.

Original languageEnglish (US)
Pages (from-to)429-436
Number of pages8
JournalTechnology in Cancer Research and Treatment
Volume4
Issue number4
DOIs
StatePublished - Aug 2005
Externally publishedYes

Keywords

  • Absorption
  • And Fluorescence
  • Contrast agent
  • Near-infrared
  • Peptide analogue conjugate
  • Prostate cancer
  • Receptor-targeted
  • Spectral polarization imaging

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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