Spectrophotometric simultaneous determination of Zinc(II), manganese(II) and iron(II) in pharmaceutical preparations using OSC-PLS

Ali Niazi, Azadeh Yazdanipour, Mohammad Goodarzi, Hamidreza Kamkar, Ali Rafinejad

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This work reports the spectrophotometric simultaneous determination of zinc(II), manganese(II) and iron(II) in pharmaceutical preparation, using orthogonal signal correction-partial least squares (OSC-PLS). All the factors affecting on the sensitivity were optimized and the linear dynamic range for determination of these metals was found. The PLS modeling was used for the multivariate calibration of the spectrophotometric data. The OSC was used for preprocessing of data matrices and the prediction results of model. The experimental calibration matrix was designed by measuring the absorbance over the range 450-570 nm for 21 samples of 0.05-1.05, 0.10-1.10 and 0.05-1.05 μg·mL-1 of zinc(II), manganese(II) and iron(II), respectively. The RMSEP for zinc(II), manganese(II) and iron(II) using OSC-PLS were 0.0164, 0.0132, 0.0146, respectively. The proposed method was successfully applied the determination of zinc(II), manganese(II) and iron(II) in pharmaceutical preparations.

Original languageEnglish (US)
Pages (from-to)1347-1350
Number of pages4
JournalChinese Chemical Letters
Issue number10
Publication statusPublished - Oct 1 2006



  • Iron(II)
  • Manganese(II)
  • Pharmaceutical
  • Spectrophotometric
  • Zinc(II)

ASJC Scopus subject areas

  • Chemistry(all)

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