Spectrum of clinical disease in a series of 135 hospitalised HIV-infected patients from north India

S. K. Sharma, Tamilarasu Kadhiravan, Amit Banga, Tarun Goyal, Indrish Bhatia, P. K. Saha

Research output: Contribution to journalArticle

74 Citations (Scopus)

Abstract

Background: Literature on the spectrum of opportunistic disease in human immunodeficiency virus (HIV)-infected patients from developing countries is sparse. The objective of this study was to document the spectrum and determine the frequency of various opportunistic infections (OIs) and non-infectious opportunistic diseases, in hospitalised HIV-infected patients from north India. Methods: One hundred and thirty five consecutive, HIV-infected patients (age 34 ± 10 years, females 17%) admitted to a tertiary care hospital in north India, for the evaluation and management of an OI or HIV-related disorder between January 2000 and July 2003, were studied. Results: Fever (71%) and weight loss (65%) were the commonest presenting symptoms. Heterosexual transmission was the commonest mode of HIV-acquisition. Tuberculosis (TB) was the commonest OI (71%) followed by candidiasis (39.3%), Pneumocystis jiroveci pneumonia (PCP) (7.4%), cryptococcal meningitis and cerebral toxoplasmosis (3.7% each). Most of the cases of TB were disseminated (64%). Apart from other well-recognised OIs, two patients had visceral leishmaniasis. Two cases of HIV-associated lymphoma were encountered. CD4+ cell counts were done in 109 patients. Majority of the patients (82.6%) had CD4+ counts <200 cells/μL. Fifty patients (46%) had CD4+ counts <50 cells/μL. Only 50 patients (37%) received antiretroviral therapy. Twenty one patients (16% died during hospital stay. All but one deaths were due to TB (16 patients; 76%) and PCP (4 patients; 19%). Conclusions: A wide spectrum of disease, including both OIs and non-infectious opportunistic diseases, is seen in hospitalised HIV-infected patients from north India. Tuberculosis remains the most common OI and is the commonest cause of death in these patients.

Original languageEnglish (US)
Article number52
JournalBMC Infectious Diseases
Volume4
DOIs
StatePublished - Nov 22 2004

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India
HIV
Opportunistic Infections
Tuberculosis
CD4 Lymphocyte Count
Pneumocystis carinii
Pneumocystis Pneumonia
Cerebral Toxoplasmosis
Cryptococcal Meningitis
Visceral Leishmaniasis
Candidiasis
Heterosexuality
Tertiary Healthcare
Tertiary Care Centers
Developing Countries
Weight Loss
Cause of Death
Lymphoma
Length of Stay
Fever

ASJC Scopus subject areas

  • Infectious Diseases

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Spectrum of clinical disease in a series of 135 hospitalised HIV-infected patients from north India. / Sharma, S. K.; Kadhiravan, Tamilarasu; Banga, Amit; Goyal, Tarun; Bhatia, Indrish; Saha, P. K.

In: BMC Infectious Diseases, Vol. 4, 52, 22.11.2004.

Research output: Contribution to journalArticle

Sharma, S. K. ; Kadhiravan, Tamilarasu ; Banga, Amit ; Goyal, Tarun ; Bhatia, Indrish ; Saha, P. K. / Spectrum of clinical disease in a series of 135 hospitalised HIV-infected patients from north India. In: BMC Infectious Diseases. 2004 ; Vol. 4.
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abstract = "Background: Literature on the spectrum of opportunistic disease in human immunodeficiency virus (HIV)-infected patients from developing countries is sparse. The objective of this study was to document the spectrum and determine the frequency of various opportunistic infections (OIs) and non-infectious opportunistic diseases, in hospitalised HIV-infected patients from north India. Methods: One hundred and thirty five consecutive, HIV-infected patients (age 34 ± 10 years, females 17{\%}) admitted to a tertiary care hospital in north India, for the evaluation and management of an OI or HIV-related disorder between January 2000 and July 2003, were studied. Results: Fever (71{\%}) and weight loss (65{\%}) were the commonest presenting symptoms. Heterosexual transmission was the commonest mode of HIV-acquisition. Tuberculosis (TB) was the commonest OI (71{\%}) followed by candidiasis (39.3{\%}), Pneumocystis jiroveci pneumonia (PCP) (7.4{\%}), cryptococcal meningitis and cerebral toxoplasmosis (3.7{\%} each). Most of the cases of TB were disseminated (64{\%}). Apart from other well-recognised OIs, two patients had visceral leishmaniasis. Two cases of HIV-associated lymphoma were encountered. CD4+ cell counts were done in 109 patients. Majority of the patients (82.6{\%}) had CD4+ counts <200 cells/μL. Fifty patients (46{\%}) had CD4+ counts <50 cells/μL. Only 50 patients (37{\%}) received antiretroviral therapy. Twenty one patients (16{\%} died during hospital stay. All but one deaths were due to TB (16 patients; 76{\%}) and PCP (4 patients; 19{\%}). Conclusions: A wide spectrum of disease, including both OIs and non-infectious opportunistic diseases, is seen in hospitalised HIV-infected patients from north India. Tuberculosis remains the most common OI and is the commonest cause of death in these patients.",
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AU - Sharma, S. K.

AU - Kadhiravan, Tamilarasu

AU - Banga, Amit

AU - Goyal, Tarun

AU - Bhatia, Indrish

AU - Saha, P. K.

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N2 - Background: Literature on the spectrum of opportunistic disease in human immunodeficiency virus (HIV)-infected patients from developing countries is sparse. The objective of this study was to document the spectrum and determine the frequency of various opportunistic infections (OIs) and non-infectious opportunistic diseases, in hospitalised HIV-infected patients from north India. Methods: One hundred and thirty five consecutive, HIV-infected patients (age 34 ± 10 years, females 17%) admitted to a tertiary care hospital in north India, for the evaluation and management of an OI or HIV-related disorder between January 2000 and July 2003, were studied. Results: Fever (71%) and weight loss (65%) were the commonest presenting symptoms. Heterosexual transmission was the commonest mode of HIV-acquisition. Tuberculosis (TB) was the commonest OI (71%) followed by candidiasis (39.3%), Pneumocystis jiroveci pneumonia (PCP) (7.4%), cryptococcal meningitis and cerebral toxoplasmosis (3.7% each). Most of the cases of TB were disseminated (64%). Apart from other well-recognised OIs, two patients had visceral leishmaniasis. Two cases of HIV-associated lymphoma were encountered. CD4+ cell counts were done in 109 patients. Majority of the patients (82.6%) had CD4+ counts <200 cells/μL. Fifty patients (46%) had CD4+ counts <50 cells/μL. Only 50 patients (37%) received antiretroviral therapy. Twenty one patients (16% died during hospital stay. All but one deaths were due to TB (16 patients; 76%) and PCP (4 patients; 19%). Conclusions: A wide spectrum of disease, including both OIs and non-infectious opportunistic diseases, is seen in hospitalised HIV-infected patients from north India. Tuberculosis remains the most common OI and is the commonest cause of death in these patients.

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