Speed congenics: A classic technique in the fast lane (relatively speaking)

Edward Wakeland, Laurence Morel, Karen Achey, Mary Yui, Jeff Longmate

Research output: Contribution to journalArticle

259 Scopus citations

Abstract

Marker-assisted selection protocol (MASP)-based strategies produce congenic strains with the target gene contained on clearly defined donor- derived genomic intervals in less than half the number of generations required by the classic protocol. Thus, the quality and speed of congenic strain construction are enhanced by this methodology. Here, Edward Wakeland and colleagues compare various MASP-based strategies and discuss their advantages with reference to immunological traits.

Original languageEnglish (US)
Pages (from-to)472-477
Number of pages6
JournalImmunology Today
Volume18
Issue number10
DOIs
Publication statusPublished - Oct 1997

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ASJC Scopus subject areas

  • Immunology

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