Spinal abnormalities in classic bladder exstrophy

Jeffrey A Cadeddu, J. E. Benson, R. I. Silver, Y. Lakshmanan, R. D. Jeffs, J. P. Gearhart

Research output: Contribution to journalArticle

22 Citations (Scopus)

Abstract

Objective. To determine the frequency and clinical sequelae of significant spinal malformations in children born with classic bladder exstrophy. Patients and methods. All patients evaluated or treated for classic bladder exstrophy at this institution were reviewed retrospectively. Radiographs or reports pertinent to the spine were retrieved and reviewed with a paediatric radiologist and all vertebral abnormalities categorized. Clinical charts of those with spinal anomalies were reviewed to determine any clinical neurological disorders associated with the radiographic findings. Results. Of 423 patients with classic bladder exstrophy who were identified, 299 had radiographs or reports available for adequate review. Of these, 34 (11%) normal variants, e.g. spina bifida occulta and lumbarization or sacralization of vertebrae, were identified. Abnormalities of spinal curvature were identified in eight patients (2.7%), all with uncomplicated scoliosis. Spinal dysraphism was diagnosed in 12 patients (4%) and included myelomeningocele, lipomeningocele, scimitar sacrum, posterior laminal defects in two or more vertebrae, vertebral fusion and hemivertebrae. The one patient with myelomeningocele had clinical neurological dysfunction, giving an overall incidence of 0.3%. Conclusions. Spinal anomalies, excluding normal variants, occur in children born with classic bladder exstrophy at a rate of about 6.7%. The incidence of this association is much less than that for cloacal exstrophy. Although rare, neurological dysfunction can occur in the case of spinal dysraphism. Paediatric urologists and neurologists should be aware of this significant difference between patients with classic bladder and cloacal exstrophy to properly diagnose, evaluate and treat the attendant neurological problems.

Original languageEnglish (US)
Pages (from-to)975-978
Number of pages4
JournalBritish Journal of Urology
Volume79
Issue number6
StatePublished - 1997

Fingerprint

Bladder Exstrophy
Meningomyelocele
Spinal Dysraphism
Spine
Spinal Curvatures
Spina Bifida Occulta
Pediatrics
Sacrum
Incidence
Scoliosis
Nervous System Diseases

Keywords

  • Exstrophy
  • Scoliosis
  • Spinal dysraphism
  • Vertebrae

ASJC Scopus subject areas

  • Urology

Cite this

Cadeddu, J. A., Benson, J. E., Silver, R. I., Lakshmanan, Y., Jeffs, R. D., & Gearhart, J. P. (1997). Spinal abnormalities in classic bladder exstrophy. British Journal of Urology, 79(6), 975-978.

Spinal abnormalities in classic bladder exstrophy. / Cadeddu, Jeffrey A; Benson, J. E.; Silver, R. I.; Lakshmanan, Y.; Jeffs, R. D.; Gearhart, J. P.

In: British Journal of Urology, Vol. 79, No. 6, 1997, p. 975-978.

Research output: Contribution to journalArticle

Cadeddu, JA, Benson, JE, Silver, RI, Lakshmanan, Y, Jeffs, RD & Gearhart, JP 1997, 'Spinal abnormalities in classic bladder exstrophy', British Journal of Urology, vol. 79, no. 6, pp. 975-978.
Cadeddu JA, Benson JE, Silver RI, Lakshmanan Y, Jeffs RD, Gearhart JP. Spinal abnormalities in classic bladder exstrophy. British Journal of Urology. 1997;79(6):975-978.
Cadeddu, Jeffrey A ; Benson, J. E. ; Silver, R. I. ; Lakshmanan, Y. ; Jeffs, R. D. ; Gearhart, J. P. / Spinal abnormalities in classic bladder exstrophy. In: British Journal of Urology. 1997 ; Vol. 79, No. 6. pp. 975-978.
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abstract = "Objective. To determine the frequency and clinical sequelae of significant spinal malformations in children born with classic bladder exstrophy. Patients and methods. All patients evaluated or treated for classic bladder exstrophy at this institution were reviewed retrospectively. Radiographs or reports pertinent to the spine were retrieved and reviewed with a paediatric radiologist and all vertebral abnormalities categorized. Clinical charts of those with spinal anomalies were reviewed to determine any clinical neurological disorders associated with the radiographic findings. Results. Of 423 patients with classic bladder exstrophy who were identified, 299 had radiographs or reports available for adequate review. Of these, 34 (11{\%}) normal variants, e.g. spina bifida occulta and lumbarization or sacralization of vertebrae, were identified. Abnormalities of spinal curvature were identified in eight patients (2.7{\%}), all with uncomplicated scoliosis. Spinal dysraphism was diagnosed in 12 patients (4{\%}) and included myelomeningocele, lipomeningocele, scimitar sacrum, posterior laminal defects in two or more vertebrae, vertebral fusion and hemivertebrae. The one patient with myelomeningocele had clinical neurological dysfunction, giving an overall incidence of 0.3{\%}. Conclusions. Spinal anomalies, excluding normal variants, occur in children born with classic bladder exstrophy at a rate of about 6.7{\%}. The incidence of this association is much less than that for cloacal exstrophy. Although rare, neurological dysfunction can occur in the case of spinal dysraphism. Paediatric urologists and neurologists should be aware of this significant difference between patients with classic bladder and cloacal exstrophy to properly diagnose, evaluate and treat the attendant neurological problems.",
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