Spinal cord metastasis in small cell carcinoma of the lung

Paul Holoye, Joseph Libnoch, James Cox, Larry Kun, Roger Byhardt, Urias Almagro, Steve McClelland, Kedar Chintapali

Research output: Contribution to journalArticle

20 Scopus citations

Abstract

Among 50 patients with small cell bronchogenic carcinoma who were placed on a protocol of combined chemotherapy and radiation therapy, seven patients developed recurrence in the spinal cord. Five cases terminated in paraplegia and death. One patient with pontine recurrence recovered with local radiation therapy. One patient, diagnosed early, responded to local radiation therapy and is ambulatory. Methods of diagnosis were myelogram, computerized axial tomography, cerebro spinal fluid, chemistry and cytologies. The poor prognosis and the difficulty of diagnosis suggest that we should evaluate prophylactic therapy of the entire cranio-spinal axis.

Original languageEnglish (US)
Pages (from-to)349-356
Number of pages8
JournalInternational journal of radiation oncology, biology, physics
Volume10
Issue number3
DOIs
StatePublished - Mar 1984

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Keywords

  • Recurrence
  • Small cell lung cancer
  • Spinal cord

ASJC Scopus subject areas

  • Radiation
  • Oncology
  • Radiology Nuclear Medicine and imaging
  • Cancer Research

Cite this

Holoye, P., Libnoch, J., Cox, J., Kun, L., Byhardt, R., Almagro, U., McClelland, S., & Chintapali, K. (1984). Spinal cord metastasis in small cell carcinoma of the lung. International journal of radiation oncology, biology, physics, 10(3), 349-356. https://doi.org/10.1016/0360-3016(84)90053-1