TY - JOUR
T1 - Spinal cord metastasis in small cell carcinoma of the lung
AU - Holoye, Paul
AU - Libnoch, Joseph
AU - Cox, James
AU - Kun, Larry
AU - Byhardt, Roger
AU - Almagro, Urias
AU - McClelland, Steve
AU - Chintapali, Kedar
PY - 1984/3
Y1 - 1984/3
N2 - Among 50 patients with small cell bronchogenic carcinoma who were placed on a protocol of combined chemotherapy and radiation therapy, seven patients developed recurrence in the spinal cord. Five cases terminated in paraplegia and death. One patient with pontine recurrence recovered with local radiation therapy. One patient, diagnosed early, responded to local radiation therapy and is ambulatory. Methods of diagnosis were myelogram, computerized axial tomography, cerebro spinal fluid, chemistry and cytologies. The poor prognosis and the difficulty of diagnosis suggest that we should evaluate prophylactic therapy of the entire cranio-spinal axis.
AB - Among 50 patients with small cell bronchogenic carcinoma who were placed on a protocol of combined chemotherapy and radiation therapy, seven patients developed recurrence in the spinal cord. Five cases terminated in paraplegia and death. One patient with pontine recurrence recovered with local radiation therapy. One patient, diagnosed early, responded to local radiation therapy and is ambulatory. Methods of diagnosis were myelogram, computerized axial tomography, cerebro spinal fluid, chemistry and cytologies. The poor prognosis and the difficulty of diagnosis suggest that we should evaluate prophylactic therapy of the entire cranio-spinal axis.
KW - Recurrence
KW - Small cell lung cancer
KW - Spinal cord
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U2 - 10.1016/0360-3016(84)90053-1
DO - 10.1016/0360-3016(84)90053-1
M3 - Article
C2 - 6323364
AN - SCOPUS:0021267719
SN - 0360-3016
VL - 10
SP - 349
EP - 356
JO - International journal of radiation oncology, biology, physics
JF - International journal of radiation oncology, biology, physics
IS - 3
ER -