Spindle Cell Lipoma of the Tongue

A Clinicopathologic Study of 8 Cases and Review of the Literature

Sean K. Lau, Justin A. Bishop, Lester D.R. Thompson

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

Spindle cell lipoma is a histologically distinct variant of lipoma characteristically arising in the subcutis of the posterior neck, upper back, or shoulder. Spindle cell lipomas infrequently occur within the oral cavity and, in particular, rarely involve the tongue. The clinical and pathologic features of eight cases of spindle cell lipoma affecting the tongue were analyzed. The study group included five men and three women ranging in age from 35 to 80 years (mean 57.4 years). Most lesions presented as either a painless or slowly growing lingual mass. The tumors were well circumscribed and characterized microscopically by a mixture of mature adipocytes, cytologically bland spindle cells, and interspersed bundles of thick collagen fibers in variable proportions. Myxoid stroma was a prominent feature in three lesions. The spindle cells were positive with CD34, while negative with S-100 protein, desmin, and smooth muscle actin. Treatment consisted of local excision in all cases. There have been no recurrences to date, with clinical follow up information available for all patients (range 11–118 months; mean 50.8 months). Lingual examples of spindle cell lipoma should be distinguished from other fat containing spindle cell neoplasms that can arise at this anatomic site.

Original languageEnglish (US)
Pages (from-to)253-259
Number of pages7
JournalHead and Neck Pathology
Volume9
Issue number2
DOIs
StatePublished - Jun 1 2015

Fingerprint

Lipoma
Tongue
Desmin
S100 Proteins
Adipocytes
Smooth Muscle
Mouth
Actins
Neoplasms
Neck
Collagen
Fats
Recurrence

Keywords

  • Lingual
  • Pleomorphic adenoma
  • Spindle cell lipoma
  • Tongue

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Otorhinolaryngology
  • Oncology

Cite this

Spindle Cell Lipoma of the Tongue : A Clinicopathologic Study of 8 Cases and Review of the Literature. / Lau, Sean K.; Bishop, Justin A.; Thompson, Lester D.R.

In: Head and Neck Pathology, Vol. 9, No. 2, 01.06.2015, p. 253-259.

Research output: Contribution to journalArticle

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