TY - JOUR
T1 - Spindle-cell variant of ameloblastic carcinoma
T2 - a report of 3 cases and demonstration of epithelial-mesenchymal transition in tumor progression
AU - McLean-Holden, Anne C.
AU - Bishop, Justin A.
AU - Kessler, Harvey P.
AU - Myers, Larry L.
AU - Radwan, Alaaaldin M.
AU - Wildey, Tyler C.
AU - Wright, John M.
AU - Cheng, Yi Shing Lisa
N1 - Publisher Copyright:
© 2019 Elsevier Inc.
PY - 2019/9
Y1 - 2019/9
N2 - Ameloblastic carcinoma is a rare odontogenic neoplasm that demonstrates the histologic characteristics of ameloblastoma, accompanied by the cytologic features of malignancy. The spindle-cell variant of ameloblastic carcinoma (SCAC) is exceptionally rare, with a total of 10 cases having been reported in the literature to date. Histologically, a prominent sarcomatoid cell population appears to originate from the epithelial (ameloblastic) component. Like conventional ameloblastic carcinoma, most cases of SCAC occur in individuals older than 40 years of age. Here, 3 additional cases of SCAC are reported, 2 of which occurred in young individuals. Diagnostic criteria to aid in the identification of SCAC are proposed. Finally, histologic and immunohistochemical evidence supporting the occurrence of epithelial–mesenchymal transition in SCAC is presented.
AB - Ameloblastic carcinoma is a rare odontogenic neoplasm that demonstrates the histologic characteristics of ameloblastoma, accompanied by the cytologic features of malignancy. The spindle-cell variant of ameloblastic carcinoma (SCAC) is exceptionally rare, with a total of 10 cases having been reported in the literature to date. Histologically, a prominent sarcomatoid cell population appears to originate from the epithelial (ameloblastic) component. Like conventional ameloblastic carcinoma, most cases of SCAC occur in individuals older than 40 years of age. Here, 3 additional cases of SCAC are reported, 2 of which occurred in young individuals. Diagnostic criteria to aid in the identification of SCAC are proposed. Finally, histologic and immunohistochemical evidence supporting the occurrence of epithelial–mesenchymal transition in SCAC is presented.
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U2 - 10.1016/j.oooo.2019.01.071
DO - 10.1016/j.oooo.2019.01.071
M3 - Article
C2 - 30928327
AN - SCOPUS:85063350524
SN - 2212-4403
VL - 128
SP - e113-e121
JO - Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology
JF - Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology
IS - 3
ER -