Splanchnic somatostatin: A hormonal regulator of nutrient homeostasis

V. Schusdziarra, E. Zyznar, D. Rouiller, G. Boden, J. C. Brown, A. Arimura, Roger H Unger

Research output: Contribution to journalArticlepeer-review

110 Scopus citations

Abstract

Free ( ∼ 1600 daltons) somatostatin-like immunoreactivity was identified in arterial plasma of dogs that had received a test meal. Neutralization of circulating somatostatin while the dogs were consuming a fatty meal increased the plasma concentrations of triglycerides, gastrin, pancreatic polypeptide, and insulin after the meal. It is concluded that, in the dog, somatostatin is a true hormone that regulates the movement of nutrients from the gut to the internal environment.

Original languageEnglish (US)
Pages (from-to)530-532
Number of pages3
JournalScience
Volume207
Issue number4430
DOIs
StatePublished - Jan 1 1980

ASJC Scopus subject areas

  • General

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