Spleen cells from animals neonatally tolerant to H-2Kk antigens recognize trinitrophenyl-modified H-2Kk spleen cells

James Forman, Jan Klein, J. Wayne Streilein

Research output: Contribution to journalArticlepeer-review

15 Scopus citations


A.TL mice injected with (A.AL × A.TL)F1 cells within 24 hours after birth were rendered tolerant to H-2Kk antigens, as evidenced by acceptance of A.TL skin grafts. When spleen cells from these tolerant animals were cocultured with A.AL stimulator cells, no cytotoxic effector cells were generated in a cell-mediated lympholysis assay. However, when the A.AL stimulator cells were derivatized with trinitrophenol, effector cells that displayed a cytotoxic effect against trinitrophenyl-modified H-2Kk target cells were generated. These data indicate that animals tolerant to H-2 determinants but chimeric to only a minor extent possess cytotoxic precursor cells in sufficient frequency to mount a primary in vitro response against trinitrophenol in the context of an allogeneic H-2K region.

Original languageEnglish (US)
Pages (from-to)561-567
Number of pages7
Issue number1
StatePublished - Dec 1 1977

ASJC Scopus subject areas

  • Immunology
  • Genetics


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